Frager, Petra (Date of defense: 2022-10-28)
[eng] Decreased physical activity and increased consumption of energy-rich food are hallmark lifestyle modifications that developed and amplified over the course of only a few decades. These changes in ...
Ramiro-Pareta, Marina (Date of defense: 2022-03-31)
The pleiotropic WT1 transcription factor (WT1) was first discovered in renal tumours. It contains four zinc-finger motifs at the C-terminus which are important for DNA binding to activate gene expression ...
Plana-Bonamaisó, Anna Maria (Date of defense: 2020-05-15)
The main aim of this work was to characterize the molecular mechanisms that underlie the physiopathology of LCA12 and RP10, that are inherited retinal dystrophies caused by alterations in guanine ...
Bagiński, Błażej Mikołaj (Date of defense: 2022-12-15)
[eng] Tumour progression largely depends on the signalling networks that direct cell viability, growth and dissemination (metastasis). Transforming growth factor beta (TGF-β) and Bone Morphogenetic ...
Ruiz Serra, Victoria Isabel (Date of defense: 2023-11-08)
[eng] Proteins are fundamental building blocks of life, and understanding their structure and function is crucial for many fields of science, from drug discovery to bioengineering. Traditional experimental ...
Estadella Pérez, Irene (Date of defense: 2023-01-20)
[eng] The voltage gated potassium channel Kv1.3 is a transmembrane protein that selectively drives potassium ions participating in the electrochemical gradient of cell membranes. This channel presents ...
Szura, Arkadiusz Damian (Date of defense: 2023-03-17)
[eng] The emergence and spread of antibiotic resistance among bacteria has become an undisputed global problem and one of the greatest threats to public health in the 21st century. The widespread, ...
Jordà Bordoy, Luis (Date of defense: 2024-02-06)
[eng] The understanding of proteins as dynamical entities rather than static structures marked a very significant advance in the interpretation of their functional role in life. The capacity of proteins ...
Privat Contreras, Cristian (Date of defense: 2023-04-20)
[eng] Intrinsically disordered proteins (IDPs) landed on the molecular biology framework at the turn of the 20th century to challenge the established protein function- structure paradigm. Due to their ...