Martín-Gago, Pablo (Date of defense: 2013-10-11)
Somatostatin, a peptidic hormone also known as somatotropin release-inhibiting factor (SRIF), is implicated in multiple biological functions, mediated by direct interaction of the peptide with a family ...
Byrom, Daniel (Date of defense: 2018-11-23)
During this doctoral thesis, we have synthesised hundreds of grams of the TGF-β inhibitor LY2157299 (Galunisertib). This product was used by the group of Eduard Batlle in their investigations into the ...
Ros Simó, Enric (Date of defense: 2020-12-16)
The present doctoral thesis has been devoted to the use of 1,2,4,5-tetrazines as potential tools for chemical biology. Tetrazines have become extremely interesting functionalities due ...
Loren Parrondo, Guillem (Date of defense: 2023-09-15)
[eng] In this doctoral thesis, the design and synthesis of bifunctional molecules that induce the degradation of a target protein in cells are described. The synthesis of molecules capable of inducing ...
Verdaguer i Espaulella, Xavier (Date of defense: 1994-07-06)
Se han estudiado las reacciones intramoleculares de Pauson-Khand de los eteres 3-alcoxialil propargílicos y 3-alcoxipropargil alílicos derivados del 2-neopentiloxi-3-bornanol y del 3-neopentiloxi-iso-borneol. ...
Martín Gómez, Helena (Date of defense: 2018-02-23)
Nowadays, the discovery and development of novel constrained peptides which are likely to combine the advantages of therapeutic proteins with those of small molecules is of special interest. This has ...
Bellido Muñoz, Marina (Date of defense: 2023-11-03)
[eng] This doctoral thesis aims to explore various synthetic methodologies and their corresponding applications in the field of asymmetric catalysis. More specifically, we have focused on the preparation ...