Flores Guri, Oscar (Date of defense: 2014-06-10)
This thesis presents a broad study of the chromatin structure and function with special focus in the nucleosome organization. More specifically, it includes three different but complementary perspectives: ...
Gallego Pérez, Diego (Date of defense: 2022-09-29)
Molecular dynamics (MD) simulations are the equivalent to a computational microscope allowing us to interrogate molecules and their behaviour in complex systems. They are recognised as a valuable and ...
Hospital Gasch, Adam (Date of defense: 2014-10-13)
Macromolecular structure, and, specifically, its dynamics and flexibility, play a crucial role in its final biological function. Intense efforts are being made to obtain experimental information about ...
Lema Amado, Rafael (Date of defense: 2020-11-19)
The connection between DNA folding and chromatin conformation has been much studied but the relation between the modulation of chromatin conformation and biological processes such as DNA damage, cell ...
Buitrago Ospina, Diana Camila (Date of defense: 2019-12-16)
Understanding the connection between DNA organization in the nucleus, and cell functioning is one of the most intriguing problems in biology. Although many interdisciplinary efforts have been developed ...
López Ferrando, Víctor (Date of defense: 2019-12-11)
Single amino acid variants (SAVs) are one of the main causes of Mendelian disorders, and play an important role in the development of many complex diseases. At the same time, they are the most common ...
Ivani, Iván (Date of defense: 2016-12-13)
Classical force fields are the core of classical simulations, particularly of molecular dynamics (MD), a technique that is changing our view on the structure, flexibility and function of biological ...