Pereira Lopes, Selma Patrícia (Date of defense: 2014-02-20)
Trex1 is an exonuclease that was first identified in mammal cells and due to its role in DNA metabolism was conjectured to have a role in DNA damage repair and cancer. It was unexpected to find that ...
Marquès Soler, Laura (Date of defense: 2002-05-10)
El procesamiento y la presentación de antígenos es un mecanismo clave en el desarrollo de la respuesta inmunitaria. En el presente trabajo, se ha estudiado la regulación de los genes <i>tap1</i> y ...
Calatayud Subias, Juan Antonio (Date of defense: 2016-07-19)
Monocytes are composed of several subsets which differ in sizes, morphology, ontogeny, localization, gene expression, fates and functions. Two principal and functionally distinct subsets have been ...
Tur Torres, Juan (Date of defense: 2017-03-22)
Mitochondria are well known for their role as bioenergetic and biosynthetic organelles. Recently, they also have emerged as one of the main regulators of innate immune responses, mostly for its ability ...
Valverde Estrella, Lorena (Date of defense: 2015-02-06)
Aicardi-Goutières Syndrome (AGS) is a rare encephalopathy which mimics a viral intrauterine infection and is characterized by calcifications of the basal ganglia, cerebral atrophy and IFN-a in the ...
Sánchez Tilló, Ester (Date of defense: 2006-05-18)
Macrophages are key regulators of immune system connecting innate and specific immune responses. Macrophages proliferate in presence of their growth factor, M-CSF. The addition of bacterial lipopolysacharide, ...
Vico Rivero, Tania (Date of defense: 2018-11-07)
El síndrome de Aicardi-Goutières (AGS) es una interferonopatía de tipo I que afecta mayoritariamente al cerebro y a la piel. Las personas afectadas tienen un nivel elevado de IFN-α en el líquido ...