Mostrando ítems 1-10 de 31
Guberović, Iva (Fecha de defensa: 2021-10-01)
The histone variant macroH2A is the only structural chromatin component containing a macrodomain. In vertebrates, two genes and one event of alternative splicing give rise to three macroH2A proteins ...
Vicioso Mantis, Marta (Fecha de defensa: 2022-09-27)
The thesis objectives resulted from previous work from Dr Martínez-Balbás lab that characterized the cooperation between TGFβ and JMJD3 to regulate transcription at enhancers, promoters, and gene ...
Shivalikanjli, Anu (Fecha de defensa: 2021-04-06)
The broad objectives of this work are the identification of genes that contribute to the susceptibility to attention-deficit/hyperactivity disorder (ADHD) and cocaine dependence, two disorders that ...
Rovira Lorente, Paula (Fecha de defensa: 2020-09-23)
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental, complex and highly heritable disorder characterised by age-inappropriate symptoms of inattention, impulsivity and hyperactivity ...
Pineda i Cirera, Laura (Fecha de defensa: 2020-09-22)
Aquesta Tesi té com a objectiu principal contribuir a l’estudi i a la identificació de factors genètics i epigenètics de susceptibilitat a les addiccions i a trastorns comòrbids, tant en humans com en ...
Rica Lázaro, Lorenzo de la (Fecha de defensa: 2014-02-14)
La presente tesis doctoral se ha centrado en investigar los procesos de desregulación en la metilación del DNA y de microRNAs en dos tipos celulares implicados en la patogenia de la artritis reumatoide, ...
Rodríguez Cortez, Virginia Carolina (Fecha de defensa: 2015-02-06)
The proper function of the immune system requires complex regulatory mechanisms and a highly strict balance in the amount and function of immune and non-immune elements. Part of the primary immunodeficiencies ...
Palma Gudiel, Helena (Fecha de defensa: 2019-02-15)
Psychiatric disorders are highly prevalent and one of the leading causes of disease burden worldwide. Nevertheless, there are no validated biomarkers to be used for either diagnostic or prognostic ...
Valdivieso Muñoz, Alejandro (Fecha de defensa: 2020-03-05)
In many organisms, sex is determined by a combination of genetic and environmental influences. Epigenetic regulatory mechanisms such as DNA methylation integrate both types of influences. However, ...
Iraola Guzmán, Susana (Fecha de defensa: 2012-12-03)
Las enfermedades neurodegenerativas, como la enfermedad de Alzheimer (EA) y la enfermedad de Parkinson (EP), representan un grave problema de salud pública, sobre todo en los países occidentales, donde ...