Delgado Martin, Gonzalo (Date of defense: 2014-07-14)
We identified proteins that interacted with the ectodomain of 4F2hc, a plasma membrane protein with dual function as heavy subunit of the amino acid transporters and positive regulator of β1 and β3 ...
Obando Martínez, Ana Zuleima (Date of defense: 2016-05-19)
Heteromeric amino acid transporters (HATs) are the unique solute transporters known to be composed of two subunits linked by a disulphide bridge. The heavy subunit (4F2hc or rBAT), a type II membrane ...
Costa i Torres, Meritxell (Date of defense: 2012-05-04)
Introduction Heteromeric amino acid transporters (HATs) are composed of a heavy subunit (rBAT or 4F2hc) and a light subunit (b0 + AT, ASC1, LAT1, LAT2, y + LAT1, y + LAT2 and xCT), joined by a disulfide ...
Álvarez Marimón, Mª Elena (Date of defense: 2014-10-27)
Heteromeric amino acid transporters (HATs) mediate the transport of amino acids through the plasma membrane. They are composed of two subunits (a heavy and a light one) linked by a conserved disulfide ...
Cano Crespo, Sara (Date of defense: 2019-06-26)
The wide variety of disorders associated with the malfunction of amino acid (AA) transporters reflect the relevant roles they fulfil in human physiology. Heteromeric AA transporters (HATs), one of the ...
Sotillo Rodríguez, Fernando (Date of defense: 2018-02-16)
Lysinuric Protein Intolerance (LPI, MIM #222700) is a rare autosomic disease caused by mutations in SLC7A7 gene. Hallmarks of LPI are malabsorption and deficient renal reabsorption of cationic amino ...