Mostrando ítems 1-10 de 110
Rey Carrizo, Matías (Fecha de defensa: 2014-11-28)
Influenza is a major health problem worldwide, as the periodic pandemics of the 20th century have highlighted. Some countermeasures have been developed and have indeed diminish the devastating effects ...
Morató Arús, Xavier (Fecha de defensa: 2017-09-29)
GPR37 is an orphan GPCR that belongs to the Rodhopsin family. GPR37 is highly expressed in the Central Nervous System (CNS), while little peripheral expression has been found in humans and rodents. GPR37 ...
Parkkola, Hanna (Fecha de defensa: 2014-12-01)
Novel stategies are needed to improve the limited efficacy of current cancer therapies. High expectations are directed towards nanotechnology-based applications in cancer medicine. We have developed a ...
Di Pietro, Ornella (Fecha de defensa: 2015-11-06)
The aim of this PhD thesis consists of the synergistic combination of both highly efficient synthetic approaches and molecular modelling tools for the structure-based drug design and synthesis of novel ...
Ghirardi, Elena (Fecha de defensa: 2016-07-28)
The first objective of this Thesis was the study of the preparation of octhydro-1H-cyclopenta[b]pyridines and octahydro-1H-indoles, through the synthesis of (R)-phenylglycinol derived tricyclic lactams. ...
Aledavood, Elnaz (Fecha de defensa: 2021-10-01)
This doctoral thesis is focused on disclosing molecular factors that regulate the functional mechanism of key targets in i) metabolic disorders, such as diabetes and obesity, and ii) tuberculosis (TB). ...
Pascual Gilabert, Marta (Fecha de defensa: 2022-11-04)
[eng] Myotonic dystrophy type 1 (DM1), one of the more complex diseases already known, is the most common and multisystemic rare neuromuscular disease among adults, without cure and limited pharmacological ...
Liu, Changxin (Fecha de defensa: 2020-10-29)
The main topic of this Thesis is to investigate the contribution of polyamines to defense in Arabidopsis thaliana and the requirement of callose deposition for full expression of effector-triggered ...
Vilaplana Saiz, Marta (Fecha de defensa: 2021-01-22)
This thesis shows the research carried out on two specific diseases: familial hypercholesterolemia, which is included within the cardiovascular diseases group, and cancer. These diseases are the major ...
Petrillo, Giovanna (Fecha de defensa: 2017-06-28)
The rapid progress in structural and molecular biology over the past fifteen years has allowed chemists to access the structures of enzymes, of their complexes and of engineered variants. This wealth ...