Garcia Cabau, Carla (Date of defense: 2022-05-31)
Intrinsically disordered (ID) proteins or regions are protein sequences that lack stable secondary and tertiary structures. ID proteins are particularly prone to undergo liquid- liquid phase separation ...
Novoa Pardo, Eva Maria (Date of defense: 2012-12-20)
Gene translation is a central process in all cells, in which messenger RNA (mRNA) is decoded by the ribosome to produce a specific amino acid chain, that will later fold into an active protein. This ...
da Rocha, Pedro Filipe Simões (Date of defense: 2022-11-25)
[eng] Treatment landscape in early-stage NSCLC is rapidly changing after approval of anti-PD-1/PD-L1 in the neoadjuvant and adjuvant settings, respectively. However, biomarkers for patient selection, ...
Solé i Codina, Laura (Date of defense: 2013-12-13)
Voltage gated potassium channels (Kv) play important roles in different biological process such as generation and propagation of the nerve pulse and the cardiac action potential, promotion of insulin ...
Glaría Percaz, Estibaliz (Date of defense: 2021-06-16)
Macrophages exert potent microbicidal functions against pathogens; however, some intracellular bacteria have developed strategies to survive within intracellular phagolysosomes and use macrophages as a ...
Brenchat Barberà, Àlex (Date of defense: 2012-03-26)
The work showed in this Thesis has been part of the “5-HT7 and neuropathic pain” project in the pharmaceutical company Esteve. Thus, the aim of this Thesis was in line with the goal of the 5-HT7 project ...
Torrealba Sandoval, Débora Alejandra (Date of defense: 2016-06-03)
El mantenimiento de la homeostasis del sistema inmune innato es fundamental, ya que éste debe mantener una respuesta equilibrada frente a los patógenos. En mamíferos, uno de los mecanismos por el cual ...
Canals Buj, Meritxell (Date of defense: 2004-04-16)
Adenosine and dopamine receptors are members of the GPCRs family for which a significant segregation between their A2A and D2 subtypes has been demonstrated in the GABAergic striopallidal neurons of the ...
Tarrado Castellarnau, Miriam Neus (Date of defense: 2015-12-11)
Cancer is characterised by the lost of physiological control and the malignant transformation of cells that acquire functional and genetic abnormalities, leading to tumour development and progression. ...
Delgado Martin, Gonzalo (Date of defense: 2014-07-14)
We identified proteins that interacted with the ectodomain of 4F2hc, a plasma membrane protein with dual function as heavy subunit of the amino acid transporters and positive regulator of β1 and β3 ...