Universitat de Barcelona: Recent submissions
Now showing items 61-80 of 11873
Nuevas metodologías para la síntesis de espiroindolinas y indoloquinolicidinas. Aplicación a la síntesis de alcaloides indólicos
[spa] Los alcaloides oxindólicos son un grupo de productos naturales caracterizados por la presencia de un sistema espiro[pirrolidina-3,3'-oxindol] y poseen una amplia gama de actividades biológicas. Por esta razón, han ...
Study of new strategies for steatotic liver disease: SIRT1-mediated modulation of VLDLR levels and evaluation of a soluble epoxyde hydrolase-targeted PROTAC
[eng] Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of chronic liver disease (CLD). The first stage in the development of MASLD is metabolic dysfunction-associated fatty liver ...
Estudio epigenómico de los factores de riesgo y pronóstico en el ictus isquémico
[spa] Introducción: El ictus es una de las principales causas de muerte a nivel mundial, siendo la primera causa para las mujeres en España. También se asocia a discapacidad, siendo su principal causa en personas adultas ...
Effect of different types of Mediterranean diet, types and quality of breakfasts, and sourdough bread on cardiometabolic risk in a population with high cardiovascular risk
[eng] Cardiovascular diseases are a major public health concern in Spain, where they are the leading cause of death. Lifestyle interventions, and diet in particular, are useful strategies to prevent cardiovascular disease ...
Modulación de genes y miRNAs desregulados en la enfermedad inflamatoria intestinal por vesiculas extracelulares de probióticos y microbiota comensal
[spa] La microbiota intestinal es importante para desarrollo del sistema inmunológico y la modulación de la barrera epitelial intestinal. La disbiosis, un desequilibrio en la microbiota, altera la homeostasis intestinal y ...
New ORR electrocatalysts and Cu-based MOFs for advanced treatment of pharmaceuticals by electro-Fenton process at near-neutral pH
[eng] Global water crisis has compelled the search for unconventional wàter resources to meet growing demands. Wastewater, being abundant and easily accessible, is increasingly recognized as resource with great added ...
Pegilación y liofilización de nanopartículas sólidas lipídicas con colesteril oleato como vectores de ácidos nucleicos
[spa] Las nanopartículas catiónicas sólidas lipídicas (cSLN) han surgido como una herramienta prometedora en terapias genéticas y de ARN. Esta investigación se enfocó en mejorar la formulación existente de SLNs con colesteril ...
Epidemiological and clinical changes, role of [18F] FDG-PET/CT in the diagnosis and management and new antibiotic treatments of cardiac implantable electronic device infections
[eng] 1. INTRODUCTION: In recent decades, there have been advances in cardiac electrostimulation (ECD) devices, with an increase in the number of implants and more sophisticated DEC, on an older target population with ...
Role of HIVEP2 in drug-tolerant persister cancer cells and tumor recurrence
[eng] Colorectal cancer (CRC) is a leading cause of death worldwide and tumor recurrence is a frequent complication that arises from minimal residual disease (MRD). Patients can relapse months or even years after an apparent ...
Development and Evaluation of Novel Baricitinib Formulation for Psoriasis Treatment
[eng] This doctoral thesis investigates the development of a lipid-based topical formulation of baricitinib for treating psoriasis, a chronic inflammatory skin condition. Psoriasis affects millions globally and presents ...
Mecanismos de señalización en el trasplante hepático de donantes con criterio extendido
[spa] En la práctica clínica, el trasplante de hígado supone una de las pocas soluciones a enfermedades hepáticas en estado terminal. Multitud de personas fallecen esperando un injerto hepático debido a la escasez de ...
Role of conjugated sterols homeostasis in plant development and stress response
[eng] Phytosterols are a family of triterpenoid compounds that occur in free form (FS) or conjugated as steryl esters (SE), steryl glycosides (SG) and acylated steryl glycosides (ASG). Free sterols and their glycosylated ...
Clinical and Neurobiological Substrates in Extreme Eating and Weight Disorders
[eng] INTRODUCTION: Extreme eating and weight conditions (EWC) represent a construct that emerges as a dimensional and theoretical model that identifies individuals who show inappropriate eating behavior and abrupt weight ...
GDF15, AMPK,PPARβ/δ : Estudio de su relación en el control de la glucemia
[spa] La diabetes mellitus tipo 2, una enfermedad multifactorial cuyo principal factor de riesgo es la obesidad, donde se produce la acumulación anormal o excesiva que puede ser dañina para la salud. Esta enfermedad se ...
CPEB4 regulation of vasculogenic mimicry in liver cancer: mechanisms and therapeutic implications
[eng] BACKGROUND: Hepatocellular carcinoma (HCC) poses a significant clinical challenge due to its complex vascular abnormalities and the regulatory mechanisms underlying tumor progression. Vasculogenic mimicry (VM), a ...
Effects of Mediterranean Diet on Cardiometabolic Biomarkers in Randomized Clinical Trials: Molecular Mechanisms
[eng] Cardiovascular diseases (CVDs) remain the leading cause of death worldwide. This global burden continues to rise due to aging populations, unhealthy diets, sedentary lifestyles, and increasing rates of obesity and ...
Explorant tres segles de col·leccions de l’Institut Botànic de Barcelona: fonts de coneixement per a diversos aspectes de la botànica i de la història de la ciència
[cat] En aquesta tesi doctoral, mitjançant l’estudi dels herbaris històrics i dels materials d’arxiu de l’Institut Botànic de Barcelona (IBB), s’amplia el coneixement sobre alguns botànics vinculats a aquestes colꞏleccions ...
Theoretical study of the interplay between structure and spectroscopy in biosystems
[eng] The interplay between structure and spectroscopy in biosystems is an important scientific challenge to understand a variety of mechanisms underlying protein function in life sciences, a challenge that requires the ...
Nanopartículas lipídicas de Apigenina y Melatonina en farmacoterapia oncológica y ocular
[spa] Los sistemas nanoestructurados lipídicos (NLC) han surgido como una herramienta prometedora en la nanomedicina, ofreciendo una gran versatilidad para la administración dirigida de fármacos. Su biocompatibilidad, ...
Exploring novel therapeutic modalities. Targeting relevant proteins in cancer
[eng] Only a small portion of the human proteome is pharmaceutically accessible based on traditional pharmacology approaches. Most proteins, for example transcription factors, scaffolding proteins and non-enzymatic ...
