Mostrando ítems 118-137 de 143
Escaja Sánchez, Nuria (Fecha de defensa: 1999-12-22)
La presente Tesis Doctoral consta de dos objetivos principales: la optimización de un método de síntesis en fase sólida para la obtención de oligonucleótidos cíclicos y el estudio estructural de diferentes secuencias ...
Fuente Cebrián, Àlex de la (Fecha de defensa: 2015-01-30)
Los iminoazúcares son productos estructuralmente análogos a los azúcares convencionales en los que un nitrógeno se sitúa sustituyendo al oxígeno endocíclico. Son sustratos capaces de mimetizar la conformación y la carga ...
Carrillo Arregui, Jokin (Fecha de defensa: 2015-11-02)
En el transcurso de esta tesis se ha trabajado en la síntesis total de la Anfidinolida B2. Ésta es una macrolactona citotóxica aislada de un dinoflagelado marino (Amphidinium sp.) por el grupo de Shimizu y colaboradores ...
Cascales Jiménez, Víctor (Fecha de defensa: 2021-12-17)
En esta Tesis doctoral se ha abordado la síntesis total de la Anfidinolida B2, un macrociclo de 25 miembros aislado por primera vez por Shimizu y colaboradores en 1994 en Brewer’s Bay, Santo Tomás, una de las Islas Vírgenes ...
Rosol, Malgorzata (Fecha de defensa: 2007-01-29)
The present Doctoral Thesis focuses in two main fields: alkyne-dicobaltcarbonyl complexes (PART I) and chiral ferrocene derivatives (PART II). Therefore, the obtained results can be summarized as follow: <br/><br/>1. The ...
Fernández Martínez, Elisabet (Fecha de defensa: 2015-01-29)
Entre los desórdenes causados por la expansión de repeticiones de trinucleótidos (TRED) se encuentra la Distrofia Miotónica de tipo 1 (DM1) causada por la expansión del triplete CTG y la Distrofia Miotónica de ...
Trapote Torres, Alejandro (Fecha de defensa: 2015-11-26)
Los IRES o Sitios Internos de Entrada Ribosomal son secuencias altamente estructuradas que se encuentran en la región no traducida del extremo 5' (5'-UTR) de diversos virus y mRNAs eucariotas que habilitan un mecanismo de ...
Romo Fernández, Juan Manuel (Fecha de defensa: 2015-06-22)
In this Doctoral Thesis a new stereoselective Ni(II)–mediated catalytic system for the SN1–like addition of chiral Nacyl thiazolidinethiones to electrophiles able to deliver cationic species under acidic conditions has ...
Maffei, Mariano (Fecha de defensa: 2014-11-03)
Objectives: Objective 1 – Effect of mutations perturbing the ULBR of the Unique domain of c-Src. The first objective of this thesis was the in vitro characterization of the effect of mutations in the ULBR on the ...
Marimon Garrido, Oriol (Fecha de defensa: 2013-09-23)
1. Introduction TomB/YmoB family of proteins was proposed as antitoxins of Hha/YmoA family of proteins. Toxin antitoxin (TA) systems are involved in the regulation of biofilm in bacteria, among other functions. Hha-TomB ...
Vázquez Jiménez, Laura (Fecha de defensa: 2014-11-25)
Oxidative stress is one of the most important factors in degenerative diseases like cancer, Alzheimer or in episodes like ischemia. During these processes, reactive species of oxygen (ROS) and nitrogen (RNS) are generated. ...
Lafuente Fabra, Maria (Fecha de defensa: 2018-07-18)
The present research project can be included in the broad supramolecular chemistry field that was defined by Nobel laureate Jean Marie Lehn as the "chemistry beyond the molecule".1 It is based on processes of molecular ...
López Asamar, Abraham (Fecha de defensa: 2015-07-17)
Prolyl oligopeptidase (POP) is an 81-KDa bidomain enzyme which hydrolyses short proline-containing peptides. This enzyme is involved in mnemonic and cognitive processes, and the dysregulation of POP activity is related to ...
Gomes, Paula Alexandra de Carvalho (Fecha de defensa: 2000-11-23)
A fast and direct surface plasmon resonance (SPR) method for the kinetic analysis of the interactions between peptide antigens and immobilised monoclonal antibodies (mAb) has been established. Protocols have been developed ...
Ros Simó, Enric (Fecha de defensa: 2020-12-16)
The present doctoral thesis has been devoted to the use of 1,2,4,5-tetrazines as potential tools for chemical biology. Tetrazines have become extremely interesting functionalities due to their ability ...
Donoghue, Craig (Fecha de defensa: 2019-07-24)
The thesis consists of two main projects: a) the development of a novel strategy to gain genetic control with spatiotemporal precision, and b) the optimisation of inhibitors of the protein kinase p38α, which has a major ...
Fransen, Peter (Fecha de defensa: 2013-12-05)
Dendrimers are a class of globular highly branched macromolecules with precise architecture. They consist of a multivalent surface with functional group, a core unit where branching starts, and the interior is made of ...
Garcia Pindado, Júlia (Fecha de defensa: 2017-05-12)
The present thesis is based on the development and optimization of a solid-phase strategy to prepare biaryl bicyclic pentapeptides. Suzuki-Miyaura cross-coupling reactions were used to obtain the biaryl bridge. The metholodogy ...
Martín-Gago, Pablo (Fecha de defensa: 2013-10-11)
Somatostatin, a peptidic hormone also known as somatotropin release-inhibiting factor (SRIF), is implicated in multiple biological functions, mediated by direct interaction of the peptide with a family of structurally ...
Pelay Gimeno, Marta (Fecha de defensa: 2013-02-15)
Pipecolidepsin A is a cyclodepsipeptide produced by a Homophymia marine sponge that has shown interesting anticancer properties against several human cancer cell lines. From a structural point of view, it is a “head-to-side-chain” ...