Garcia Pindado, Júlia (Date of defense: 2017-05-12)
The present thesis is based on the development and optimization of a solid-phase strategy to prepare biaryl bicyclic pentapeptides. Suzuki-Miyaura cross-coupling reactions were used to obtain the biaryl ...
Isidro Llobet, Albert (Date of defense: 2008-05-13)
The increasing importance of peptides as drugs creates the necessity of new methodologies for the synthesis of complex peptides. This PhD thesis has been focused on the development of new protecting ...
Tapia Pérez, Lucía (Date of defense: 2021-10-01)
This PhD thesis lays on the field of supramolecular chemistry. In this field, there is a huge interest in the development of cage-like compounds able to bind biologically relevant molecules inside their ...
Martín-Gago, Pablo (Date of defense: 2013-10-11)
Somatostatin, a peptidic hormone also known as somatotropin release-inhibiting factor (SRIF), is implicated in multiple biological functions, mediated by direct interaction of the peptide with a family ...
Díaz Perlas, Cristina (Date of defense: 2018-03-07)
Peptides play a critical role in human physiology and harbour a huge potential as therapeutic agents. In this thesis, new peptides have been discovered as ligands for the epidermal growth factor (EGF) ...
Fernández-Llamazares Onrubia, Ana Iris (Date of defense: 2013-12-09)
Backbone N-methylation is becoming an increasingly important tool in peptide drug design, and has been widely used to optimize the activity and selectivity of peptide ligands as a result of conformational ...
Vilaprinyó Pascual, Sílvia (Date of defense: 2015-07-27)
Amyloid-beta protein (Aß) is strongly linked to the aetiology of Alzheimer’s disease (AD). Even though Aß has a central role in AD, this protein is normally produced in healthy humans. It is the aberrant ...
Góngora Benítez, Miriam (Date of defense: 2013-02-08)
Synthesis of Cys-containing peptides has long been posed as an attractive challenge for peptide chemist. Protecting groups for the nucleophilic beta-thiol group of Cys residues must be stable during ...
Oller Salvia, Benjamí (Date of defense: 2015-05-18)
Brain delivery is a major unmet challenge because most drugs cannot cross the blood-brain barrier (BBB). Despite the restrictive nature of this barrier, brain vasculature reaches essentially every neural ...
Elduque Busquets, Xavier (Date of defense: 2014-09-05)
This work is divided in 2 different parts: Part A: Cyclization and conjugation can confer on biomolecules better activity, resistance toward enzymatic degradation and better internalization ...