Gordo Villoslada, Susana (Date of defense: 2008-06-30)
Protein-protein interactions are essential in biological processes and thus, they have become very promising therapeutic targets. Nevertheless, the artificial modulation of protein complexes remains a ...
Khaizourane, Héléa (Date of defense: 2016-03-11)
The Pauson-Khand reaction (PKR), introduced by Pauson and Khand in 1973, is an efficient method to access the synthesis of five-membered rings in one single step. This reaction is a transition metal-mediated ...
Le Roux, Anabel-Lise (Date of defense: 2015-11-18)
c-Src is the leading member of the Src family of non-receptor tyrosine kinases, which are involved in many signaling pathways. Its deregulation affects cell migration, proliferation and survival. c-Src ...
Elduque Busquets, Xavier (Date of defense: 2014-09-05)
This work is divided in 2 different parts: Part A: Cyclization and conjugation can confer on biomolecules better activity, resistance toward enzymatic degradation and better internalization ...
Mas Moruno, Carlos (Date of defense: 2009-03-05)
La sepsis es un síndrome muy complejo de definir, diagnosticar y tratar. La patología de la sepsis se deriva de una respuesta perjudicial del organismo a una infección. La exposición a endotoxinas ...
Herraiz Cobo, Jesús (Date of defense: 2017-07-13)
Mayotlide is a marine peptide isolated by PharmaMar S.A. from Spongia sp.. The sequence of the aminoacids were achieved by MS-MS spectrometry, where two of them were tryptophans. The NMR spectroscopy ...
Ramos Tomillero, Iván (Date of defense: 2016-07-15)
Cancer is a heterogeneous disease that represents one of the principal causes of mortality in developed countries. Due to the social and economic implications of this pathology, tremendous efforts have ...
Grau Campistany, Ariadna (Date of defense: 2014-07-17)
The global emergence and spread of multidrug-resistant bacteria is an important public health issue. However, the antimicrobial pipeline remains unacceptably lean, in fact over the last 25 years, the ...
Vila Farrés, Xavier (Date of defense: 2014-11-14)
Nowadays in the world there is a very big problem associated with two factors related to each other. The first factor is the increase in the resistant of certain bacteria, especially the bacteria from ...
Marimon Garrido, Oriol (Date of defense: 2013-09-23)
1. Introduction TomB/YmoB family of proteins was proposed as antitoxins of Hha/YmoA family of proteins. Toxin antitoxin (TA) systems are involved in the regulation of biofilm in bacteria, among other ...