Loren Parrondo, Guillem (Date of defense: 2023-09-15)
[eng] In this doctoral thesis, the design and synthesis of bifunctional molecules that induce the degradation of a target protein in cells are described. The synthesis of molecules capable of inducing ...
Ninot Pedrosa, Martí (Date of defense: 2018-03-02)
Amyloid-beta peptide (Aβ) is strongly linked to the aetiology of Alzheimer’s disease (AD). Aβ is the main component of the amyloid plaques found in the brain of AD patients, however, Aβ is also present ...
Riefolo, Fabio (Date of defense: 2020-07-29)
Modern medical treatments are largely based on the ability of pharmacological drugs to interact with a molecular target in the human body (e.g., receptors) in order to evoke a physiological response. ...