Nicolini, Federica (Date of defense: 2022-12-02)
[eng] Protein-protein interactions (PPIs) play a crucial role in the homeostasis of the cells; therefore, they are important therapeutic targets. Typically, the goal in targeting PPIs is to impede them. ...
Panarello, Silvia (Date of defense: 2021-12-15)
Photopharmacology has the main purpose to allow the control of protein activity with light. The most exploited strategy used to achieve this objective is the freely diffusible photopharmacology and it ...
Frigolé Vivas, Marta (Date of defense: 2020-09-23)
[eng] Drug discovery is the process by which new drugs are found and developed into the market. Given the scope of this thesis, the term “drug” will refer to small molecules and the term “target” to ...
Matarín Morales, Joan Antoni (Date of defense: 2021-12-15)
Peptides are defined as compounds that contain between two and fifty amino acids connected together by amide bonds. Inside our body, peptides are natural biological messengers that play critical roles ...
Loren Parrondo, Guillem (Date of defense: 2023-09-15)
[eng] In this doctoral thesis, the design and synthesis of bifunctional molecules that induce the degradation of a target protein in cells are described. The synthesis of molecules capable of inducing ...
Riefolo, Fabio (Date of defense: 2020-07-29)
Modern medical treatments are largely based on the ability of pharmacological drugs to interact with a molecular target in the human body (e.g., receptors) in order to evoke a physiological response. ...
Gómez García, Roberto (Date of defense: 2023-12-15)
[spa] La presente Tesis de carácter multidisciplinar se centra en el diseño y síntesis de nuevos derivados de C75 como potenciales agentes antitumorales e inhibidores de la ingesta para el desarrollo ...
Santiago Piera, Raul (Date of defense: 2024-02-16)
[eng] Organic chemistry is recognized for its ability to arrange a limited set of atoms in numerous ways, a quality that is crucial in molecular magnetism. This branch benefits from the adaptability of ...