Miret Casals, Laia (Date of defense: 2014-05-23)
CHAPTER 1: Respiratory Infectious Diseases (RID) are diseases affecting the air passages, the bronchi and the lungs. They range from acute infections, such as pneumonia and bronchitis, to chronic ...
Postma, Tobias Maria (Date of defense: 2014-03-21)
Cysteine (Cys) is a unique amino acid due to its ability to form reversible covalent disulfide bonds. These bonds cause conformational constraints which make peptides or proteins more rigid and stable. ...
Pereira de Magalhaes e Couto, Miguel (Date of defense: 2014-11-10)
The main subject of this Thesis is the production of hard, wear and corrosion resistant cermets tungsten carbide and cobalt cermets (WC-Co) with different contents in cobalt matrix, onto low carbon ...
Mendieta Martínez, Laura (Date of defense: 2014-06-06)
Proteases are involved in a high number of diseases, and thus, are relevant targets. For that reason our main goal was the discovery of protease inhibitors as therapeutic agents. We focused our study ...
Zamudio Vázquez, Rubí (Date of defense: 2014-02-14)
Triostins are members of the quinoxaline antibiotic family, together with the "prototypical bisintercalator" echinomycin. These molecules display interesting antitumour activities as they inhibit ...
Serra Vidal, Bernat (Date of defense: 2014-05-27)
Alzheimer’s disease (AD) is a neurodegenerative disorder which major risk factor is age. Current drugs only offer symptomatic alleviation in AD, thus a disease-modifying treatment is urgent. The amyloid-β ...
Guixer, Bernat (Date of defense: 2014-03-31)
The blood-brain barrier (888) is a biological barrier that plays a crucial role protecting the brain from neurotoxic agents and regulating the influx and efflux of molecules required for the correct ...
Sánchez Martínez, Melchor (Date of defense: 2014-12-09)
Proteins are flexible entities, and thus move. Its function is closely related to the flexibility. To carry out any function is necessary a conformational change. As protein motions imply an exchange ...
Portell Bueso, Anna (Date of defense: 2014-11-17)
This thesis is a multidisciplinary study of the solid state of squaric acid derivatives which combines approaches from areas such as crystal engineering, supramolecular chemistry and crystallography. ...