Universitat Pompeu Fabra
Mostrando ítems 3091-3110 de 3222
La tesi doctoral aquí presentada busca entendre quin és el paper de les proteïnes d’unió a l’ARN en la progressió tumoral, ja que s’ha demostrat que aquestes proteïnes poden regular aspectes que permeten o inhibeixen la ...
The Lower Rhombic Lip (LRL) is a transient neuroepithelial structure of dorsal hindbrain that gives rise to deep brainstem nuclei like the vestibular, auditory and precerebellar nuclei. In this work, we have followed the ...
The activity of the brain at rest reveals an intricate functional architecture and yet, the underlying mechanisms generating it are still not well understood. Whole-brain computational models have turned into fundamental ...
Alternative pre-mRNA splicing is a regulated step in eukaryotic gene expression in which introns are removed from the transcript and exons are joined together to form a mature mRNA. To study the effects of mutations on ...
The pathologic role of senescent cells is well established in a variety of diseases. Despite the ample evidence that mitochondria play a central role in cellular senescence, the understanding of the adaptations in the ...
When watching television, many people use social media to share real-time opinions and feelings. The mediated co-viewing is widely studied under the name of “second screen” or “social TV”. In Japan and China, a technology ...
This thesis has been about the use of a simulation technique, known as molecular dynamics simulations, to study biophysics in proteins that have historically been difficult to study with other methods. We have studied ...
L’estudi de la variació estructural complementa l’estudi de la variació de seqüència per revelar les complexitats de la variació fenotípica. Els gossos són l’espècie domesticada amb més variació fenotípica que existeix ...
According to estimates, over the 3.5 billion years that have elapsed since the appearance of life, the Earth has been inhabited by some 4 billion different species, of which 99.99% have already become extinct. Extinction ...
T-cell homeostasis must be tightly regulated and maintained in order to guarantee appropriate immune responses and prevent immunopathology. This maintenance depends on MHC-TCR interaction and cytokine-mediated signals among ...
The EBV has been linked to multiple human disease phenotypes and has been associated with cancers and other infections. Recently single gene analysis and genome-wide analysis studies have been exploited to uncover the human ...
Understanding how receptor-ligand interactions occur is a first step towards designing new drugs. The complete reconstruction of the binding process in a drug-receptor system provides all the physical-chemistry variables ...
Three microtubule (MT) assembly pathways participate in the assembly of the bipolar spindle: the centrosomal pathway, the augmin dependent amplification pathway and the RanGTP/chromosome dependent pathway. To form the ...
Rearrangements involving the mixed lineage leukemia gene (MLL) are found in majority of human infant leukemias (>60% of ALLs, 35% of AMLs) and are associated with dismal prognosis of these patients. They are also found in ...
Advanced societies have witnessed unprecedented socioeconomic and technological changes in the last 50 years. The growth of the service sector has transformed the class structure, and social mobility has increased for ...
The three chapters included in this dissertation aim to improve our understanding of the distance between people's desires regarding the timing and the number of children they want to have and what they finally achieve. ...
Cancer is a disease of the genome. The study of tumor genomic alterations is used to guide several precision medicine strategies, some approved and a large number under clinical development. On the other hand, the study ...
La aplicación de la radiación ionizante (RI) en ámbito médico ha llegado, sin duda, para salvar vidas. Sin embargo, hay una preocupación entre los expertos de salud pública y protección radiológica con relación al incremento ...
Los inhibidores de PARP han surgido como nuevas terapias basadas en el papel essencial de las Poly (ADP-ribosa) polimerasas PARP-1 y PARP-2 en la respuesta a daño en el DNA, explotando el efecto de las mismas en la célula ...
Aquesta tesi investiga els mecanismes de formació i evolució de gens de novo utilitzant seqüenciació massiva de transcrits complerts i de fragments protegits per ribosomes. Hem identificat milers de gens de novo en humans ...
