Understanding the mechanisms of de novo gene evolution using transcriptomics data 

Ruiz Orera, Jorge (Date of defense: 2017-01-19)

Aquesta tesi investiga els mecanismes de formació i evolució de gens de novo utilitzant seqüenciació massiva de transcrits complerts i de fragments protegits per ribosomes. Hem identificat milers de gens de novo en humans ...

Understanding the molecular basis of neuronal 3'UTR length-dependent mRNA sorting 

Grawenhoff, Julia (Date of defense: 2024-01-24)

The local translation of messenger RNAs (mRNAs) within different neuronal compartments is a prerequisite the formation of long-term memories. mRNAs are localized via active transport along microtubules, however, the ...

Understanding the molecular mechanisms involved in Notch1 induced T-cell acute lymphoblastic leukemia 

D'Altri, Teresa (Date of defense: 2013-07-26)

Understanding the nationalization of party 

Simón Cosano, Pablo (Date of defense: 2011-11-03)

This thesis is focused on the nationalization of party systems in Western Europe and combines four different approaches. Despite the literature claiming that political decentralization reduces party system nationalization, ...

Understanding the political integration outcomes of enfranchised and high socioeconomic status immigrants in host societies 

Nguyen, My Land Do (Date of defense: 2020-01-31)

The purpose of this dissertation is to systematically investigate the theoretical perspective that political power derives from socioeconomic power—a fundamental tenet of both sociological theories of assimilation and ...

Understanding the role of body weight and composition on lung function growth and decline 

Prado Peralta, María Gabriela (Date of defense: 2020-07-14)

Background: There is evidence suggesting that body weight is associated with lung function, but results are contradictory and suffer from important limitations. We aimed to assess the association of body weight and composition ...

Understanding the role of polyglutamylation in the mitotic spindle 

Zadra, Ivan (Date of defense: 2022-03-17)

To ensure faithful segregation of the genetic material, cells build the mitotic spindle, a machinery made of dynamic microtubules (MTs) and MT associated proteins (MAPs). Chromosome bi-orientation is achieved through the ...

Understanding the social brain : neurocogntive effetcs of experiencing a social hierarchy 

Santamaría-García, Hernando (Date of defense: 2014-01-31)

The present research is aimed at analyzing how human’s brain jointly computes cognitive and social interactions in presence of implicit social stimuli and/or in presence of socially neutral stimuli. First we analyzed the ...

Understanding the transcriptional landscape of non-coding genome in mammals 

Bogu, Gireesh K. (Date of defense: 2017-01-13)

Widespread transcription in mammals revealed unexpected discovery of non-coding elements like long noncoding RNAs (lncRNAs) and repetitive elements. First, lncRNAs were previously identified in limited number of tissues ...

Unemployment in local labor markets : empirics and theory 

Morron Salmeron, Adrià (Date of defense: 2017-05-30)

The existence of transportation costs gives labor markets a local dimension. In particular, the well-documented existence of agglomeration economies creates a positive correlation between a city's size and the productivity ...

Unidad léxica y significado especializado: modelo de representación a partir del nombre relacional madre 

Adelstein, Andreina (Date of defense: 2007-02-16)

Esta tesis estudia la especificidad de los significados léxicos especializados, a partir del análisis del funcionamiento de nombres relacionales; ofrece una explicación integrada de la semántica especializada y no especializada ...

Unidades de conocimiento especializado para la traducción jurídica: identificación y propuesta de representación de la equivalencia del derecho de extranjería en un diccionario bilingüe español-rumano 

Cornea, Ioana (Date of defense: 2015-05-18)

El objetivo de esta Tesis doctoral es identificar las unidades de conocimiento especializado del derecho de extranjería con el fin de representar la relación de la equivalencia en un diccionario bilingüe español-rumano ...

Unidades fraseológicas especializadas eventivas: descripción y reglas de formación en el ámbito de la energía solar 

Bevilacqua, Cleci Regina (Date of defense: 2004-06-11)

Esta tesis tiene como objeto de estudio las Unidades Frasológicas Especializadas Eventiv as (UFE eventivas), definidas como unidades sintagmáticas formadas por uno o más términos, que se componen de un núcleo terminológico ...

Unidades léxicas especializadas para la didáctica del chino: análisis de necesidades y propuesta 

Xu, Yingfeng (Date of defense: 2020-06-23)

Esta tesis doctoral tiene como finalidad principal analizar la situación de la enseñanza de la lengua china en España, concretamente en Barcelona, y en toda su complejidad, para proponer la introducción de léxico ...

Unraveling luminal breast cancer heterogeneity 

Figueras Puig, Cristina (Date of defense: 2022-04-08)

Metastasis is the major cause of death from Breast Cancer (BCa). During its progression, divergent opinions have arisen regarding the hormonal status of the BCa subtypes. The mammary gland is composed of different cell ...

Unraveling novel roles of the cellular decapping activators Lsm1-7 and Dhh1 in translation control through viral studies 

Jungfleisch, Jennifer (Date of defense: 2015-03-20)

Translation control is a vital aspect of gene expression for both viruses and their cellular hosts. We have previously shown that the cellular mRNA decay activators Dhh1 and Lsm1-7 promote translation of positive-strand ...

Unraveling the complex signaling behavior of neurotransmitters and their receptors in the brain 

Stepniewski, Tomasz Maciej (Date of defense: 2020-01-09)

G protein-coupled receptors (GPCRs) are the main acceptors of neurotransmitters, and thus play an important role in communication between neurons. Because of this they are an attractive drug target for multiple neurodegenerative ...

Unraveling the functional roles of sftb-1/SF3B1 and prpf-4/PRPF4B in Caenorhabditis elegans splicing and human disease 

Serrat Farran, Xènia (Date of defense: 2019-11-26)

Caenorhabditis elegans provides a powerful experimental system for understanding fundamental questions in biomedical research, including the consequences of pre-mRNA splicing alterations. Here, we have applied CRISPR and ...

Unraveling the molecular mechanisms involved in RCAN-peptide mediated inhibition of calcineurin-NFAT signaling and its potential as an inhibitor of tumor progressions 

Martínez Høyer, Sergio (Date of defense: 2012-10-11)

The calcineurin-NFATc signaling pathway is involved in many aspects of the development and function of the immune, neural, skeletal, cardiovascular and muscular system of vertebrates. Regulators of Calcineurin (RCAN) ...

Unravelling integrated kinetics during spindle assembly 

Cavazza, Tommaso (Date of defense: 2015-10-30)

To ensure faithful segregation of the genetic material, during mitosis the cell assembles the mitotic spindle, a macromolecular machine made of dynamic microtubules and associated proteins. Spindle microtubules are assembled ...