Universitat Pompeu Fabra
Now showing items 3122-3141 of 3215
To ensure faithful segregation of the genetic material, during mitosis the cell assembles the mitotic spindle, a macromolecular machine made of dynamic microtubules and associated proteins. Spindle microtubules are assembled ...
Numerous studies have shown that the protein kinase IKKα is associated with cancer progression and metastasis in different models. However, the mechanisms underlying IKKα tumorigenic functions are poorly understood. We ...
The presence of an extra copy of Human Chromosome 21 (HSA21) in Down syndrome (DS) is one of the most complex genetic perturbations compatible with life and is the most common genetic cause of intellectual disability. Here, ...
Environmental stress is a major aspect of life and a limiting factor for the survival and distribution of species. Understanding the organismal stress response and the developed coping mechanisms is indispensable in order ...
Microexons are an unusual form of alternative splicing with high evolutionary conservation, however, their functions are still far from being understood. In this thesis, we focused on a neuronal-specific microexon that ...
This doctoral work focuses on identifying and understanding the intents that motivate a user to perform a search on the Web. To this end, we apply machine learning models that do not require more information than the one ...
This thesis studies parametric optimization in cellular and cell-free networks, exploring data-based and expert-based paradigms. Power allocation and power control, which adjust the transmit power to meet different fairness ...
La organización del genoma en células mamíferas sigue siendo en gran parte desconocida. Un nivel fundamental de organización se considera el bucle de cromatina, que consiste en una región de ADN atrapada en el interior ...
Opisthokonta is an eukaryotic supergroup that contains Metazoa, Fungi and their unicellular relatives. Therefore, this group provides an ideal framework to study distinct unicellular-multicellular transitions, among them, ...
Precise regulation of neurogenesis is achieved by differentially allocating the neurogenic competence along the tissue. In the hindbrain proneural gene expression is stereotypically confined in segment boundary-adjacent ...
The generation of cell diversity in the embryonic brain relies on the balance between cell proliferation and differentiation. The hindbrain boundary cells specify at the interface between adjacent compartments. Boundary ...
Understanding the determinants of childhood obesity has never been more urgent given the high levels across the world. It is increasingly recognized that the urban environment may affect childhood growth and obesity, and ...
Urban environments are very complex systems with a myriad of factors intricately related. Built environment, transport, physical activity and sedentary behaviours, air pollution, and social contacts and feelings of loneliness ...
Urban design influences how we go about our lives and even how we feel about our neighbors. Using data from the Copernicus Urban Atlas, I find that residents of cities across Europe that have more continuous urban fabric ...
Urban renewal interventions aim to improve physical infrastrucutres, promote social integration and increase economic gains. However, they also have the potential to improve the wellbeing of residents. The objective of ...
Press reports and stories about the idea of the asocial have taken place successively in Barcelona since the beginning of the twentieth century. They range from the Lliga Regionalista’s fear of the barbarians to the ...
The object of study of this thesis is a special case of translation: the Anglophone literature of writers of Caribbean or Latin American origin in the United States translated into Spanish. This case is special because of ...
Williams-Beuren syndrome (WBS) is a neurodevelopmental disorder caused by the common deletion of 26-28 contiguous genes in the 7q11.23 region, which poses difficulties to the establishment of genotype-phenotype correlations. ...
This thesis aims to analyse the use of digital networks as a tool for electoral communication by new political organisations. Thus, the research study is focused on Barcelona 2015 city council election and the political ...
The main objective of this thesis is to carry out a multidisciplinary study of the behavior of microblog users. To that end we first explore several user behavior patterns employing data mining techniques. Then we use ...
