Plana Carmona, Marcos (Date of defense: 2021-03-17)
Continuous C/EBPa expression converts B cells into macrophages while its transient upregulation before the Yamanaka factors yields highly efficient iPSC reprogramming. C/EBP members regulate Il6 ...
Traveset Martínez, Laia (Date of defense: 2020-10-30)
Maintenance of steady-state and stress-adapted hematopoiesis depends on the fitness of hematopoietic stem and progenitor cells (HSPCs) in the bone marrow. Hematopoietic stem cells (HSCs) can adapt to ...
Mestre Farràs, Neus (Date of defense: 2021-09-16)
La tesi doctoral aquí presentada busca entendre quin és el paper de les proteïnes d’unió a l’ARN en la progressió tumoral, ja que s’ha demostrat que aquestes proteïnes poden regular aspectes que permeten ...
Severino, Jacqueline (Date of defense: 2021-03-30)
X chromosome reactivation in female mouse germ cells is essential for the transmission of one active X chromosome to the progeny. However, despite its key role in development, the mechanistic details and ...
Mantica, Federica (Date of defense: 2023-05-11)
Regulated Gene Expression (rGE) and Alternative Splicing (rAS) are two of the main mechanisms contributing to tissue-phenotypic diversity within and between species. In this thesis, we aim at characterizing ...
Pich Roselló, Oriol (Date of defense: 2021-03-24)
Cells of our body are constantly exposed to events that can create lesions in the DNA. If unremoved by the DNA repair mechanisms, the lesion may lead to a mutational event. Some of these events might ...
Cabrerizo Granados, David (Date of defense: 2020-11-30)
Snail1 is a transcriptional factor with a great relevance in tumor development as it is required for epithelial to mesenchymal transition and activation of cancer-associated fibroblasts (CAF). In this ...
Sebastián Perez, Rubén (Date of defense: 2021-09-10)
Chromocenters are established after the 2-cell (2C) stage during mouse embryonic development, but the factors that mediate chromocenter formation remain largely unknown. To identify regulators of 2C ...
Tu, Xiaochuan (Date of defense: 2023-07-27)
Embryonic stem cells (ESCs) are derived from the inner cell mass of the pre-implantation embryo and can recapitulate early developmental stages of the embryo. ESCs have the ability to continuously ...
Dan, Yuzhen (Date of defense: 2022-02-24)
p38α (encoded by MAPK14) is a major regulator of cellular responses to almost all types of environmental and intracellular stresses. Upon activation, p38α phosphorylates various substrates both in the ...