Mostrando ítems 161-170 de 174
Bosch Morató, Mònica (Fecha de defensa: 2015-07-17)
The Amyloid β-peptide (Aβ) is accumulated in several diseases including GNE myopathy and Alzheimer’s disease (AD). GNE myopathy is a skeletal muscle disorder caused by biallelic mutations in the ...
Herrero Vicente, Jorge (Fecha de defensa: 2024-02-26)
Cancer cells exhibit a synthetic lethal (SL) phenotype when Myc upregulation is combined with antitumor drugs targeting the splicing factor SF3B1. However, the molecular events and mechanisms responsible ...
López Polo, Vanessa (Fecha de defensa: 2024-03-07)
The pathologic role of senescent cells is well established in a variety of diseases. Despite the ample evidence that mitochondria play a central role in cellular senescence, the understanding of the ...
Condemi, Livia (Fecha de defensa: 2024-03-07)
Polycomb repressive complex (PRC) 2 is one of the key regulators of the transcriptional programs, it maintains stem cell properties and guides cell lineage specification. It is a multiprotein complex ...
Hong, Xiaotong (Fecha de defensa: 2022-10-06)
La regeneración del músculo esquelético depende de la expansión correcta de las células madre inactivas residentes (células satélite), un proceso que se vuelve menos eficiente con el envejecimiento, por ...
Vineethakumari Muraleedharan, Chithran (Fecha de defensa: 2024-03-14)
Microtubules form diverse arrays according to the cell type or the cell cycle stage to facilitate the context-specific functions of the cytoskeleton. One way by which cells achieve this is by restricting ...
Sondermann, Nathalie Allegra Faye (Fecha de defensa: 2024-03-21)
Polycomb repressive complexes (PRC1/2) are key chromatin regulators in development. Their deregulation is implicated in various cancers including leukaemia. Meanwhile, MLL-rearrangements by chromosomal ...
Suárez Ara, Patricia (Fecha de defensa: 2024-04-12)
The origin of animals has puzzled scientists for centuries. The transition from a unicellular eukaryote to animals is undoubtedly one of the biggest evolutionary transitions in Earth’s history. To unravel ...
Martínez Corral, Rosa (Fecha de defensa: 2018-09-28)
In this Thesis we have studied how dynamics and space modulate cellular behaviour, by means of mathematical modelling of particular biological examples. At the single cell level, we show how pulsatile ...
Aguilar Fernández, Sergio (Fecha de defensa: 2024-04-24)
The intrinsic complexity and dynamic nature of B-lymphocytes make them ideal for in-depth analysis using single-cell technologies. Secondary lymphoid organs (SLOs) are central in B-lymphocyte activation ...