Pupuleku, Aldi (Date of defense: 2017-11-10)
Human cytomegalovirus (HCMV) infection induces a persistent reconfiguration of the NK cell compartment in some individuals, promoting the development of a mature NK cell subset, hallmarked by high ...
Bosch Morató, Mònica (Date of defense: 2015-07-17)
The Amyloid β-peptide (Aβ) is accumulated in several diseases including GNE myopathy and Alzheimer’s disease (AD). GNE myopathy is a skeletal muscle disorder caused by biallelic mutations in the ...
Herrero Vicente, Jorge (Date of defense: 2024-02-26)
Cancer cells exhibit a synthetic lethal (SL) phenotype when Myc upregulation is combined with antitumor drugs targeting the splicing factor SF3B1. However, the molecular events and mechanisms responsible ...
López Polo, Vanessa (Date of defense: 2024-03-07)
The pathologic role of senescent cells is well established in a variety of diseases. Despite the ample evidence that mitochondria play a central role in cellular senescence, the understanding of the ...
Condemi, Livia (Date of defense: 2024-03-07)
Polycomb repressive complex (PRC) 2 is one of the key regulators of the transcriptional programs, it maintains stem cell properties and guides cell lineage specification. It is a multiprotein complex ...
Hong, Xiaotong (Date of defense: 2022-10-06)
La regeneración del músculo esquelético depende de la expansión correcta de las células madre inactivas residentes (células satélite), un proceso que se vuelve menos eficiente con el envejecimiento, por ...
Vineethakumari Muraleedharan, Chithran (Date of defense: 2024-03-14)
Microtubules form diverse arrays according to the cell type or the cell cycle stage to facilitate the context-specific functions of the cytoskeleton. One way by which cells achieve this is by restricting ...
Sondermann, Nathalie Allegra Faye (Date of defense: 2024-03-21)
Polycomb repressive complexes (PRC1/2) are key chromatin regulators in development. Their deregulation is implicated in various cancers including leukaemia. Meanwhile, MLL-rearrangements by chromosomal ...
Suárez Ara, Patricia (Date of defense: 2024-04-12)
The origin of animals has puzzled scientists for centuries. The transition from a unicellular eukaryote to animals is undoubtedly one of the biggest evolutionary transitions in Earth’s history. To unravel ...
Martínez Corral, Rosa (Date of defense: 2018-09-28)
In this Thesis we have studied how dynamics and space modulate cellular behaviour, by means of mathematical modelling of particular biological examples. At the single cell level, we show how pulsatile ...