Bascones Gleave, Sabrina (Date of defense: 2016-12-20)
The spleen contains a unique subset of innate-like marginal zone (MZ) B cells that rapidly mount protective antibody responses to invasive encapsulated bacteria. Here we show that human splenic MZ B ...
Costa García, Marcel (Date of defense: 2018-06-11)
Human cytomegalovirus (HCMV) infection induces persistent changes in the host immune system, namely a sustained expansion of effector memory and cytotoxic specific T lymphocytes, the production of ...
Cebrià i Costa, Joan Pau (Date of defense: 2017-06-29)
L’oxidació de la histona 3 en la lisina 4 (H3K4ox) per acció de la lysil oxidase-like 2 (LOXL2) genera una nova modificació de la H3 amb una funció desconeguda. En aquesta tesi, hem determinat tant en ...
Pascual-Reguant, Laura (Date of defense: 2018-11-23)
Les làmines nuclears (A/C i B) són els majors constituents de la làmina nuclear (NL). Els estructuralment conservats dominis associats a les làmines (LADs) estan formats per regions genòmiques que ...
Luis, Nuno Miguel (Date of defense: 2011-11-07)
Human epidermis relies on a population of adult stem cells to maintain its homeostasis. Stem cells transit from a dormant to an active state and undergo a tightly regulated process of differentiation ...
Tolosa Ramon, Queralt (Date of defense: 2023-07-26)
The outer epithelial layer is the first cell type that emerges during development, providing essential mechanical protection and is indispensable for morphogenesis. Here, we study how the interplay ...
Klischies, Sabine (Date of defense: 2015-07-15)
Microtubules (MTs) are part of the cytoskeleton in eukaryotic cells and are nucleated by the γ-tubulin ring complex (γTuRC), at the centrosome, which is also called the MTOC (microtubule organizing ...
Gabrielli, Natalia (Date of defense: 2012-12-04)
Hydrogen peroxide (H2O2), a reactive oxygen species (ROS), is involved in both oxidative stress and signaling cascades in a dosage dependent manner. Its toxicity is partially explained through reactivity ...
Engel-Pizcueta, Carolyn (Date of defense: 2023-04-28)
The generation of cell diversity in the embryonic brain relies on the balance between cell proliferation and differentiation. The hindbrain boundary cells specify at the interface between adjacent ...
Kozyczkowska, Aleksandra (Date of defense: 2022-03-11)
To address one of the most fascinating questions in the history of life, the origin of animal multicellularity, we needed experimentally tractable representatives from each of the unicellular lineages, ...