Lunazzi, Giulia (Date of defense: 2013-06-06)
Stimulation of Toll-like receptors (TLRs) in cells of the innate immune system activates the expression of a proinflammatory and antimicrobial gene program controlled by a network of transcriptional ...
Arató, Krisztina (Date of defense: 2010-12-20)
DYRK1A is the most studied member of the DYRK family of protein kinases, because is one of the human chromosoma 21 proteins for which changes in gene dosage result in neuropathological alterations. DYRKs ...
Sánchez Muñoz, Raúl (Date of defense: 2018-11-29)
Plant secondary metabolism generates a wide range of molecules, some of them with valuable pharmacological properties. Taxanes are a good example, as since their discovery no other compound has shown ...
Teichmann, Sophie (Date of defense: 2013-02-04)
La monoubiquitinación de la histona H2A cumple un rol esencial en la represión génica. Diversas enzimas desubiquitinantes (DUBs) han sido identificadas, que remueven específicamente la ubiquitina de ...
Bleda Latorre, Marta (Date of defense: 2015-11-27)
Gene regulation is a complex biological process that requires the coordinated interaction of different molecules. The integrity of the underlying mechanisms ensures the correct expression of genes that ...
Hänzelmann, Sonja (Date of defense: 2012-10-11)
In the last decade, molecular biology has expanded from a reductionist view to a systems-wide view that tries to unravel the complex interactions of cellular components. Owing to the emergence of ...
Núñez Ollé, Marc (Date of defense: 2014-07-04)
Cyclin O, a novel identified CDK1 and CDK2-binding cyclin, has been demonstrated to be required for γ-radiation induced apoptosis in a lymphoid cell line. Ɣ-radiation induces the formation of DSBs in ...
Stanley, Nathaniel H. (Date of defense: 2015-04-24)
This thesis has been about the use of a simulation technique, known as molecular dynamics simulations, to study biophysics in proteins that have historically been difficult to study with other methods. ...
Domènech Guil, Alba (Date of defense: 2018-03-02)
Schizosaccharomyces pombe, com tots els organismes aeròbics, requereix l’oxigen per viure i té que lidiar amb la conseqüent toxicitat associada dels productes derivats de l’oxigen. Per mantenir l’ambient ...
Cirillo, Davide (Date of defense: 2016-05-09)
The purpose of my doctoral studies has been the development of bioinformatics methods to quantitatively evaluate associations between proteins and nucleic acids (NAs). This thesis aims at providing ...