Rai, Madhulika (Date of defense: 2018-01-29)
Genetically tractable model organisms may help to identify new approaches to stop malignant growth. During the first part of my doctoral thesis, I have participated in a high content screen carried ...
Reymond, Loïc (Date of defense: 2023-09-20)
This thesis introduces SIMPLE (Structured Illumination based Point Lo- calization Estimator), a novel super-resolution technique in fluorescence microscopy. By combining standing-wave patterned illumination ...
Pérez Culubret, Adrià (Date of defense: 2022-01-27)
Caracteritzar la dinàmica de les proteïnes és essencial per tal d'entendre la connexió entre seqüència i funció. La simulació de dinàmiques moleculars és una de les tècniques principals per a estudiar ...
Moldón Vara, Alberto (Date of defense: 2008-10-17)
The meiotic cell cycle is modified from the mitotic cell cycle by having a premeiotic S phase which leads to high levels of recombination, two rounds of nuclear division with no intervening DNA synthesis, ...
Cort, Rianne Angelica (Date of defense: 2019-12-13)
The kinase DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a dosage-sensitive gene, since both haploinsufficiency and overexpression when in trisomy lead to pathological phenotypes in humans. ...
Gómez Gómez, Àlex (Date of defense: 2022-07-08)
Els biomarcadors són un conjunt de signes mèdics objectius que són molt rellevants en l'àmbit clínic. La metabolòmica és la tècnica d'elecció per a establir biomarcadors. Centrar-se en una família ...
Gibert Fernandez, Joan (Date of defense: 2017-11-08)
Cytoplasmic polyadenylation binding proteins (CPEB) are a family of RNA binding proteins which control the translation of its target mRNAs by modulating the length poly(A) mRNA tail. Cytoplasmic ...
Campos Mata, Leire de (Date of defense: 2019-12-18)
The highly conserved exonuclease Xrn1 plays a dual role in gene expression by degrading cellular mRNAs and promoting their transcription initiation and elongation. In this thesis we uncover an unanticipated ...
Ruggiano, Annamaria (Date of defense: 2015-05-26)
La función, forma e identidad de los orgánulos celulares es determinada, en gran medida, por su composición lipídica y proteica. Para mantener el equilibrio celular, las tasas de síntesis y degradación ...
Guixà González, Ramon (Date of defense: 2014-07-23)
La composición lipídica de las membranas celulares determina en última instancia sus propiedades biofísicas, afectando así las dinámicas y organización de proteinas transmembrana claves como los receptores ...