Jorba Argemí, Guillem (Date of defense: 2023-04-13)
El procés de descobriment i desenvolupament de fàrmacs (DDD) és costós tant econòmic com temporalment, i el qual resulta en nivells d'èxit molt reduïts. Una gran quantitat de compostos son analitzats i ...
Stojakovic, Predrag (Date of defense: 2023-03-06)
Cell volume regulation is essential for cellular homeostasis and adaptation to environmental osmotic changes. Upon hyperosmotic stress, cells need to rapidly restore osmotic balances in order to preserve ...
Cianferoni, Damiano (Date of defense: 2023-10-09)
Aquesta tesi presenta diversos avenços que inclouen: (i) noves funcionalitats afegides a la “suite” d'eines de disseny de proteïnes FoldX per permetre als usuaris treballar amb qualsevol tipus de molècula; ...
Militti, Cristina (Date of defense: 2013-07-26)
En Drosophila, el desequilibrio en cuanto al contenido de genes ligados al cromosoma X entre hembras (XX) y machos (XY) es corregido mediante la duplicación de la transcripción del único cromosoma X del ...
Lunazzi, Giulia (Date of defense: 2013-06-06)
Stimulation of Toll-like receptors (TLRs) in cells of the innate immune system activates the expression of a proinflammatory and antimicrobial gene program controlled by a network of transcriptional ...
Arató, Krisztina (Date of defense: 2010-12-20)
DYRK1A is the most studied member of the DYRK family of protein kinases, because is one of the human chromosoma 21 proteins for which changes in gene dosage result in neuropathological alterations. DYRKs ...
Sánchez Muñoz, Raúl (Date of defense: 2018-11-29)
Plant secondary metabolism generates a wide range of molecules, some of them with valuable pharmacological properties. Taxanes are a good example, as since their discovery no other compound has shown ...
Teichmann, Sophie (Date of defense: 2013-02-04)
La monoubiquitinación de la histona H2A cumple un rol esencial en la represión génica. Diversas enzimas desubiquitinantes (DUBs) han sido identificadas, que remueven específicamente la ubiquitina de ...
Bleda Latorre, Marta (Date of defense: 2015-11-27)
Gene regulation is a complex biological process that requires the coordinated interaction of different molecules. The integrity of the underlying mechanisms ensures the correct expression of genes that ...
Hänzelmann, Sonja (Date of defense: 2012-10-11)
In the last decade, molecular biology has expanded from a reductionist view to a systems-wide view that tries to unravel the complex interactions of cellular components. Owing to the emergence of ...