Ara mostrant els elements 1-8 de 8
Demajo Meseguer, Santiago (Data de defensa: 2014-02-21)
Acute myeloid leukemia (AML) is frequently linked to epigenetic abnormalities and deregulation of gene transcription, which lead to aberrant cell proliferation and accumulation of undifferentiated ...
González Ramírez, Mar (Data de defensa: 2021-03-19)
Appropriate regulation of gene expression is necessary for correct development and homeostasis of organisms. Epigenetic mechanisms represent an additional layer of information, besides the genetic ...
Rinaldi, Lorenzo (Data de defensa: 2016-10-17)
DNA methylation is an essential epigenetic mechanism that regulates gene expression. While DNA methylation dynamics during embryonic formation is fairly well understood, its role in adult tissues is ...
Espejo Díaz, María Isabel (Data de defensa: 2021-09-20)
Polycomb group (PcG) proteins are transcriptional repressors that control development and cell fate. Polycomb Repressive Complex 2 (PRC2) misfunction has been recurrently associated with embryonic ...
Jain, Payal (Data de defensa: 2015-06-11)
Polycomblike proteins (PCLs) have been shown to regulate Polycomb Repressive Complex 2 (PRC2) by enhancing its catalytic activity and guiding PRC2 to its target genes in embryonic stem cells. However, ...
Chammas, Paul (Data de defensa: 2019-11-29)
Polycomb repressive complex 2 (PRC2) is a key epigenetic regulator of gene expression. It acts through its histone-modifying activity, as it is responsible of di- and trimethylating the tail of histone ...
Uribesalgo Micàs, Iris (Data de defensa: 2010-11-24)
The c-Myc transcription factor is a key player in cell homeostasis, being commonly deregulated in human carcinogenesis. In this PhD thesis we have addressed the question how regulatory mechanisms ...
Morey Ramonell, Lluís (Data de defensa: 2008-02-01)
En mamíferos, así como en plantas, mutaciones en AND helicasas/ATPasas del la família SNF2, no solo afectan a la estructura de la cromatina, sino que también afectan al patrón global de la metilación ...