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Estudi de l'acció de diferents bloquejadors de la via ErbB en la teràpia antitumoral 

Ferrer Soler, Laura (Date of defense: 2007-03-30)

L'inhibidor de carboxipeptidasa de patata (PCI) és un antagonista de l'EGF. Un dels problemes del PCI, però, és la baixa afinitat per l'EGFR en comparació amb el lligand natural. En aquest treball s'han ...

Role of alpha 2,3-sialyltransferases ST3Gal III and ST3Gal IV in pancreatic ductal adenocarcinoma 

Pérez Garay, Marta (Date of defense: 2011-02-07)

Este trabajo demuestra que los genes que codifican para los enzimas beta-galactosido alfa-2,3-sialiltransferasa 3 (ST3Gal III), y en menor medida beta-galactosido alfa-2,3-sialiltransferasa 4 (ST3Gal ...

Structural and functional characterization of Apoptin and design of a monomeric variant with antitumor activity 

Ruiz Martínez, Santiago (Date of defense: 2016-07-08)

The main aim of the present study is to characterize the biological and biophysical properties of Apoptin, a viral protein that selectively induces apoptosis of a wide range of tumor cells. Apoptin has ...

El Inhibidor de carboxipeptidasa de patata (PCI): un antagonista del EGF con actividad antitumoral 

Blanco Aparicio, Carmen (Date of defense: 1998-07-17)

In this work we report that potato carboxypeptidase inhibitor suppresses the growth of several human and mouse pancreatic adenocarcinoma cell lines. The inhibitor also reduces the growth of solid tumors ...

Bioenergetics mechanism and autophagy in breast cancer stem cells 

Cufí González, Sílvia (Date of defense: 2015-05-22)

Aquest és el primer informe que demostra que l'autofàgia està mecànicament vinculat al manteniment de les cèl•lules tumorals que expressen alts nivells de CD44 i baixos nivells de CD24, que són típics ...

Pancreatic cancer markers based on aberrant glycosylation of serum proteins 

Balmaña Esteban, Meritxell (Date of defense: 2016-07-07)

Cancer is one of the leading causes of death worldwide. Pancreatic ductal adenocarcinoma (PDAC) is characterized by high intrinsic aggressiveness and late diagnosis, causing poor prognosis and resulting ...

Antitumoral properties of epidermal growth factor derivatives 

Panosa Roqueta, Clara (Date of defense: 2015-12-14)

The members of the epidermal growth factor (EGF) / ErbB family are prime targets for cancer therapy. However, the therapeutic efficiency of the existing anti-ErbB agents is limited. Thus, identifying ...

Study of the anticancer activity of a nuclear directed HP-RNase variant and different metal-based compounds 

Bravo Bonilla, Marlon Rolando (Date of defense: 2022-06-16)

Cancer is the leading cause of death due to non-communicable diseases worldwide. Despite the advances in the development of new antitumor drugs, there are still problems such as the resistance that tumor ...

Altered glycosylation in pancreatic cancer: development of new tumor markers and therapeutic strategies 

Guerrero Barrado, Pedro Enrique (Date of defense: 2020-07-29)

Pancreatic Ductal Adenocarcinoma (PDA), the most common pancreatic cancer, remains one of the most lethal tumor types, with extremely low survival rates due to late diagnosis and resistance to standard ...

Nous factors inflamatoris de la diabetis tipus 2: SP-D, SP-A, a-Defensives i visfatina 

Chico Julià, Berta (Date of defense: 2009-02-19)

La DM 2 és una malaltia multifactorial i multigènica. Aquest fet condueix a l'estudi de molts gens i proteïnes susceptibles d'estar implicades amb la DM 2. Algunes d'aquestes proteïnes i gens estan ...

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Cancer (4)

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616 (18)

577 - Material bases of life. Biochemistry. Molecular biology. Biophysics (12)

576 - Cellular and subcellular biology. Cytology (4)

575 - General genetics. General cytogenetics (2)

615 - Pharmacology. Therapeutics. Toxicology (1)

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