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  2. Universitat de Girona
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Anàlisi de la vehiculització de compostos metàl·lics com a agents antitumorals i de la família HER-EGF en la resistència als tractaments oncològics 

Carrion-Salip, Dolors (Date of defense: 2014-09-17)

Most current chemotherapeutic agents are of limited use due to their side effects and the resistance to treatment that tumour cells develop. In this thesis, we have contributed to the knowledge of these ...

Nous mecanismes de resistència primària al trastuzumab (Herceptin): bases moleculars per a la determinació d'un nou subtipus de càncer de mama (Basal/ErbB2+) 

Oliveras Ferrarós, Cristina (Date of defense: 2013-06-21)

The aim of this doctoral thesis was to unravel mechanisms underlying primary resistance to trastuzumab regarding a putative new breast cancer subtype with mixed basal & ErbB2+ molecular features. Using ...

Dehiscencia de anastomosis en la cirugía del cáncer de recto: incidencia, factores pronósticos y morbimortalidad asociada 

Farrés Coll, Ramon (Date of defense: 2023-03-10)

Introduction: Anastomotic leak (AL) is the most feared complication in the postoperative period for patients with rectal cancer. Objectives: To determine the real rate of AL in patients operated on ...

Inhibition of sialyltransferases in pancreatic cancer: effects on the EGFR pathway and on the tumour phenotype 

Miró Domènech, Laura (Date of defense: 2023-01-13)

Pancreatic ductal adenocarcinoma (PDA) presents a dismal prognosis mainly due to its delayed diagnosis, its aggressiveness, and resistance to existing therapies. Aberrant glycosylation and, in particular, ...

Glycan alterations of serum proteins as tumour markers. Prostate-specific antigen in prostate cancer and acute-phase proteins in pancreatic cancer 

Sarrats Carbó, Ariadna (Date of defense: 2011-02-10)

Els pacients amb càncer presenten una taxa de supervivència superior si es diagnostiquen a estadis inicials, per la qual cosa és indispensable disposar de marcadors tumorals adequats. Glicoformes de ...

Estudi de l'acció de diferents bloquejadors de la via ErbB en la teràpia antitumoral 

Ferrer Soler, Laura (Date of defense: 2007-03-30)

L'inhibidor de carboxipeptidasa de patata (PCI) és un antagonista de l'EGF. Un dels problemes del PCI, però, és la baixa afinitat per l'EGFR en comparació amb el lligand natural. En aquest treball s'han ...

New tumour markers for pancreatic cancer based on the altered glycosylation of serum glycoproteins 

Duran Sidera, Adrià (Date of defense: 2023-11-14)

Pancreatic cancer (PaC) is the deadliest of all tumours, with a 5-year survival below 12% and a mortality/incidence ratio of 94.5%. One of the main reasons behind this dismal prognosis is the diagnosis ...

Nous factors inflamatoris de la diabetis tipus 2: SP-D, SP-A, a-Defensives i visfatina 

Chico Julià, Berta (Date of defense: 2009-02-19)

La DM 2 és una malaltia multifactorial i multigènica. Aquest fet condueix a l'estudi de molts gens i proteïnes susceptibles d'estar implicades amb la DM 2. Algunes d'aquestes proteïnes i gens estan ...

Factors pronòstics en la dehiscència anastomòtica de la cirurgia del càncer de còlon. Models de predicció actuals i validació externa independent 

Pigem Rodeja, Anna (Date of defense: 2023-03-03)

INTRODUCTION: Anastomotic leak (AL) is the most dreadful and life-threatening complication in colon cancer (CC) surgery. It is associated to an increase of morbimortality, longer hospital stay, increased ...

Antitumoral properties of epidermal growth factor derivatives 

Panosa Roqueta, Clara (Date of defense: 2015-12-14)

The members of the epidermal growth factor (EGF) / ErbB family are prime targets for cancer therapy. However, the therapeutic efficiency of the existing anti-ErbB agents is limited. Thus, identifying ...

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Director

Peracaula Miró, Rosa (6)

Llorens Duran, Rafael de (4)

Llop Escorihuela, Esther (3)

Benito i Mundet, Antoni (2)

Codina Cazador, Antoni (2)

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Date of defense

2020 - 2025 (12)

2010 - 2019 (9)

2000 - 2009 (2)

1998 - 1999 (1)

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English (13)

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Keywords and Knowledge Area

Càncer de pàncrees (6)

Cáncer de páncreas (6)

Pancreatic cancer (6)

Marcadores tumorales (5)

Marcadors tumorals (5)

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Subjects

616 (24)

577 - Biochemistry. Molecular biology. Biophysics (14)

576 - Cellular and subcellular biology. Cytology (4)

616.3 - Pathology of the digestive system. Complaints of the alimentary canal (4)

575 - General genetics. General cytogenetics. Immunogenetics. Evolution. Phylogeny (3)

... Show more

Full text availability

Open access (21)

Embargoed access (3)

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