Now showing items 316-335 of 457
Barbosa, João Moura (Date of defense: 2019-05-24)
Our ability to memorize is at the core of our cognitive abilities. How could we effectively make decisions without considering memories of previous experiences? Broadly, our memories can be divided in two categories: ...
Moreno Monasterio, Marta (Date of defense: 2015-02-18)
The main goal of this PhD thesis was to understand the mechanisms underlying GBM tumor formation and progression, with a special emphasis on the study of factors that have a role in normal NSC biology, which might be ...
Candela Cantó, Santiago Antonio (Date of defense: 2019-01-16)
ANTECEDENTS: Per a l’adequat diagnòstic i/o tractament dels pacients amb epilèpsia refractària o trastorns del moviment es requereix la implantació d’elèctrodes cerebrals en alguns casos seleccionats. HIPÒTESIS: El robot ...
Laporta-Hoyos, Olga (Date of defense: 2018-10-08)
INTRODUCCIÓN: La parálisis cerebral es una de las causas más frecuentes de discapacidad física en niños y supone una condición que persiste a lo largo de la vida (Krageloh-Mann & Cans, 2009). Concretamente, la prevalencia ...
Ariño Rodríguez, Helena (Date of defense: 2017-03-28)
This thesis focuses on antibodies against the glutamic acid decarboxylase (GAD-ab) in neurological disorders. GAD-ab were first identified in 1988 in the serum and CSF from one patient with stiff-person syndrome (SPS) and ...
Abolafia Moya, Juan Manuel (Date of defense: 2011-02-02)
La adaptación que ocurre en el sistema auditivo es un fenónemo que todos experimentamos cuando dejamos de oir sonidos irrelevantes, constantes o incluso molestos. La adaptación para sonidos conocidos aumenta también la ...
Recalde-Percaz, Leire (Date of defense: 2021-06-30)
Metastases are considered the last stage of tumour progression and the main cause of death associated to solid tumours. There are no effective treatments for metastasis which remain non- curable with more than 90% of ...
Caballero Díaz, Daniel (Date of defense: 2018-02-09)
Hepatocellular Carcinoma (HCC) is one of the most common cancers. During hepatocarcinogenesis (a multistep process) there is a disruption of the balance between cell death and survival signalling pathways, where pro-apoptotic ...
Lucariello, Mario (Date of defense: 2017-03-16)
STUDY I HYPOTHESIS Genetic alterations have already been recognized as major etiological factors for ASD and ID, of which RTT is an example. In addition to the contribution of polymorphic variants that confer low or ...
Quintanilla Leo, Isabel (Date of defense: 2017-07-20)
Colorectal cancer (CRC) is one of the most frequent malignancies worldwide and it is considered an important healthcare problem. Moreover, colorectal carcinogenesis is a long stepwise process through a known precursor, the ...
López Luque, Judit (Date of defense: 2016-11-23)
Transforming growth factor-beta (TGF-β) is an important growth suppressor in hepatocytes, inhibiting proliferation and inducing cell death. However, it also plays a role in other processes such as epithelial-to-mesenchymal ...
Mira Martínez, Sofía (Date of defense: 2018-02-23)
Malaria is responsible of almost half a million deaths every year. Currently, campaigns for the control and elimination of malaria are implemented in malaria endemic areas. However, drug resistance is one of the major ...
Monteiro D'Albuquerque, Polyana (Date of defense: 2015-06-15)
Antiretroviral therapy has dramatically reduced morbidity and mortality associated with HIV-1 infection and converted AIDS into a manageable chronic disease. During the past 15 years, antiretroviral drugs have become less ...
Baró Sastre, Bàrbara (Date of defense: 2013-09-20)
La sortida de mitosis comprèn tots els processos de la mitosis que van des de la segregació de les cromàtides germanes a l’obtenció de dues cèl·lules filles genèticament idèntiques. A nivell molecular, les cèl·lules inicien ...
Alberghina, Nadia (Date of defense: 2018-12-04)
INTRODUCCIÓN: la ultrasonografía endoscópica (USE) y la punción aspirativa con aguja fina guiada por USE (USE-PAAF) han demostrado su utilidad en gran número de situaciones clínicas durante los últimos 20 años. El hecho ...
Villanueva Verdejo, Eneko (Date of defense: 2016-03-11)
El cáncer de páncreas es la cuarta causa de muerte por cáncer en los países industrializados. En 2030, las predicciones señalan que puede pasar a ser la segunda. Pese a la relativa baja incidencia de este tipo de cáncer, ...
Rojas Liévano, Jhon Fredy (Date of defense: 2019-01-24)
La infección por el virus de la inmunodeficiencia humana (VIH) continúa siendo un problema importante de salud pública mundial. En 2017 aproximadamente 36,9 millones de personas eran portadoras del VIH (incluidos 1,8 ...
Fernández Carrillo, Carlos (Date of defense: 2017-02-01)
La infección por VHC constituye un problema mundial de primer orden, siendo la primera causa de trasplante hepático en todo el mundo. Se trata de un patógeno muy adaptado a humanos, probablemente durante miles de años en ...
Mollica, Maria Antonella (Date of defense: 2017-05-05)
En la última década, frente al fracaso de los tratamientos farmacológicos para detener el proceso patológico de la enfermedad de Alzheimer, la fase preclínica se ha convertido en un importante foco de investigación, puesto ...
Cardesa Salzmann, Teresa (Date of defense: 2014-01-21)
La presente tesis incluye dos trabajos: PRIMER TRABAJO High microvessel density determines a poor outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus chemotherapy Cardesa-Salzmann ...