Browsing Departament de Química Inorgànica i Orgànica by Subject "547"

Advances in Asymmetric Catalytic Reactions: Novel Methodologies and Synthetic Applications

Bellido Muñoz, Marina (Date of defense: 2023-11-03)

[eng] This doctoral thesis aims to explore various synthetic methodologies and their corresponding applications in the field of asymmetric catalysis. More specifically, we have focused on the preparation of prochiral ...

Aminocyclitol and iminosugar derivatives related to Gauche disease

Monlleó Mas, Ester (Date of defense: 2016-11-25)

Gaucher disease (GD) is one of the most prevalent lysosomal storage diseases.A mutation on gene gba1 generates a misfolded enzyme acid β-glucosidase. Due to this, this enzyme is not properly transported from the endoplasmic ...

Aproximació a la síntesi de la iriomoteolida-2a i avaluació in silico de la interacció amb actina. Intents d’un nou mètode de RCM amb formació de dobles enllaços trisubstituïts

Marco Correas, Cristian (Date of defense: 2019-10-23)

La present Tesi Doctoral descriu tots els esforços dedicats a la síntesi total de la iriomoteolida- 2a, un nou macròlid aïllat per Tsuda i col·laboradors a l’illa d’Iriomote (Japó) l’any 2015. Exhibeix una moderada ...

Bioconjugació de poliols i tiols amb agents antivírics

Petit Roig, Elena (Date of defense: 2019-10-29)

El VIH-1 segueix essent un dels problemes més greus de la sanitat pública mundial, especialment als països del tercer món. La fase més avançada de la infecció pel VIH és la SIDA (síndrome d’immunodeficiència adquirida). La ...

Carbazole-Based Materials for Organic Thin-Film Transistors and Organic Light-Emitting Diodes

Reig Canyelles, Marta (Date of defense: 2017-07-07)

This thesis deals with the preparation and characterization of novel organic semiconductors based on the carbazole heterocycle for electronic and optoelectronic applications, specifically to be studied as active layers in ...

Computational insights into carbohydrate epimerase mechanisms

Esquivias Bautista de Lisbona, Oriol (Date of defense: 2023-11-17)

[eng] Carbohydrates, as the most abundant biomolecules, play a myriad of roles and functions in biological systems. Unlike the building blocks of proteins, amino acids, whose chemical structure can vary significantly, ...

Coordination, organometallic and supramolecular chemistry approaches to the design of metal-based cytotoxic agents

Faustino Brissos, Rosa Maria (Date of defense: 2018-04-13)

The discovery of cisplatin and its successful use as chemotherapeutic agent have encouraged the development of metal-based anticancer molecules. The present doctoral research project includes three different chemistry ...

COUPY coumarins as privileged scaffolds for the development of novel targeted fluorophores and metalbased PDT anticancer agents

Rovira Vidal, Anna (Date of defense: 2023-03-03)

[eng] In this Thesis, we have explored the applications in cancer diagnosis and therapy of COUPY fluorophores, a new family of compounds based on the coumarin structure and operating in the far-red to near infrared region ...

Desenvolupament de processos per a la síntesi de pèptids d’interès terapèutic a escala industrial

Duran Corbera, Macarena (Date of defense: 2021-09-30)

Investigacions recents en el camp de la biomedicina han demostrat que les interaccions entre pèptids i macromolècules com ara les proteïnes, modulen i regulen processos biològics importants com la memòria, la resposta a ...

Design and preparation of functional coordination compounds based on poly-β-diketone and polypyrazolyl ligands

Borilović, Ivana (Date of defense: 2018-11-23)

Combining the judiciously designed bis−β-diketone and polypyrazolyl scaffolds with the crystal field effects on the 3d metal ions, this manuscript exposes different methods of selective preparation of new heterometallic ...

Design and synthesis of selective MMP-9 inhibitors for the treatment of epilepsy

Bertran Junqué, Alexandra (Date of defense: 2018-10-25)

Matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases involved in the degradation of the extracellular matrix. They make a major contribution to the progression of a vast number of diseases, ...

Design of Catalytic Systems based on Halogen Bonding Interactions: Synthesis and Application in Catalytic Reactions

Martínez Bascuñana, Alba (Date of defense: 2023-09-01)

[eng] The use of supramolecular interactions in catalysis has been widely studied and exploited for the straightforward preparation of the backbones of an array of structurally diverse stereoselective catalysts. In addition ...

The development of new, direct and asymmetric Ni(II) catalysed carbon-carbon bond forming reactions and their application to total synthesis

Kennington, Stuart (Date of defense: 2020-12-21)

This thesis focuses on the search for new methodologies for the direct, stereoselective and catalytic formation of carbon-carbon bonds through the formation of chiral nickel(II) enolate species and the application of such ...

Development of novel nanomedicines based on polyurethane-polyurea hybrid nanocapsules for cancer theragnosis

Bonelli Blasco, Joaquin Daniel (Date of defense: 2022-12-14)

[eng] Nanomedicine is one of the cutting-edge fields in most of medical applications, specially, in oncology. The possibility to selectively vehiculize and specifically release a wide range of anticancer compounds gained ...

Diarylethene-based Pt(II) molecular switches: a novel approch to photoactivated chemotherapy

Presa i Rodríguez, Andreu (Date of defense: 2016-12-16)

The photoactivation of metal complexes with potential anticancer activity is a hot topic of current research, as it may lead to the development of more selective and efficient drugs. Photoactivated chemotherapy (PACT) with ...

Drug discovery with a FRET Biosensor of scaffolding interactions in the N-terminal region of c-Src = Descubrimiento de fármacos mediante un biosensor basado en FRET sensible a las interacciones en la región N-terminal de c-Src

Iruela Martin, Guillermo (Date of defense: 2021-09-16)

c-Src tyrosine kinase is associated with poor prognosis in many cancer processes. Although inhibitors of c-Src kinase activity are known, they have not reached success in clinical trials because of lack of selectivity or ...

Enolates Go Radical. Stereoselective Radical Alkylation Reactions of Titanium Enolates from N-Acyl Oxazolidinones with Carboxylic Acid Derivatives. Synthesis of Umuravumbolide

Pérez Palau, Marina (Date of defense: 2022-07-08)

This thesis consists in the development of a new methodology of α-alkylation of carbonyl compounds and its application to the synthesis of small molecules with therapeutic interest. In this context, the alkylation of ...