Arbesú Andrés, Miguel (Date of defense: 2018-03-02)
c-Src is a central player in several cellular signaling pathways. It controls impor- tant cellular processes like cellular proliferation, survival or motility. Therefore, a number of tumoral diseases ...
Llorens Palomo, Lluís (Date of defense: 2019-10-28)
Cucurbiturils are known to present potential applications in molecular recognition, self- assembly, and nanotechnology. The discovery of ultra-high affinity CB–guest complexes with binding constant ...
Velasquez Benites, Juan Diego (Date of defense: 2022-07-14)
The structure and stability of molecules, the formation of supramolecular aggregates in the solid state or in solution and, therefore, many chemical and biological processes in which they participate ...
Pérez Palau, Marina (Date of defense: 2022-07-08)
This thesis consists in the development of a new methodology of α-alkylation of carbonyl compounds and its application to the synthesis of small molecules with therapeutic interest. In this context, the ...
Segovia Laserna, Rosario (Date of defense: 2022-03-08)
After decades of exorbitant antibiotic misuse and overuse in human medicine, agriculture and livestock industry, multidrug resistant bacteria (MDR) have become a major medical concern. In this regard, ...
Monlleó Mas, Ester (Date of defense: 2016-11-25)
Gaucher disease (GD) is one of the most prevalent lysosomal storage diseases.A mutation on gene gba1 generates a misfolded enzyme acid β-glucosidase. Due to this, this enzyme is not properly transported ...
Mohammad Jabeen, Irrem Laareb (Date of defense: 2021-09-23)
c-Src is a non-receptor tyrosine kinase that controls numerous cellular signaling pathways. c-Src implication in human cancers was brought into the attention in the 1980s. Since its discovery, ...
Kennington, Stuart (Date of defense: 2020-12-21)
This thesis focuses on the search for new methodologies for the direct, stereoselective and catalytic formation of carbon-carbon bonds through the formation of chiral nickel(II) enolate species and the ...
Lobo Ruiz, Ariadna (Date of defense: 2019-05-10)
Peptides and proteins are essential substances for living organisms, as they can be found in every cell and tissue and are involved in many biological and physiological processes. Given their intrinsic ...
Mir Morro, Bartomeu (Date of defense: 2019-11-22)
Given the increasing interest in i-motif structures, obtaining such structures as well as detailed structural information under physiological conditions have become hot topics in the structural biology ...