Mancinelli, Andrea (Date of defense: 2017-04-21)
The development of selective methods for the direct conversion of carbon−hydrogen bonds into carbon-heteroatom and carbon−carbon bonds remains a critical challenge in organic chemistry. An interesting ...
Faustino Brissos, Rosa Maria (Date of defense: 2018-04-13)
The discovery of cisplatin and its successful use as chemotherapeutic agent have encouraged the development of metal-based anticancer molecules. The present doctoral research project includes three ...
Arbesú Andrés, Miguel (Date of defense: 2018-03-02)
c-Src is a central player in several cellular signaling pathways. It controls impor- tant cellular processes like cellular proliferation, survival or motility. Therefore, a number of tumoral diseases ...
Llorens Palomo, Lluís (Date of defense: 2019-10-28)
Cucurbiturils are known to present potential applications in molecular recognition, self- assembly, and nanotechnology. The discovery of ultra-high affinity CB–guest complexes with binding constant ...
Velasquez Benites, Juan Diego (Date of defense: 2022-07-14)
The structure and stability of molecules, the formation of supramolecular aggregates in the solid state or in solution and, therefore, many chemical and biological processes in which they participate ...
Pérez Palau, Marina (Date of defense: 2022-07-08)
This thesis consists in the development of a new methodology of α-alkylation of carbonyl compounds and its application to the synthesis of small molecules with therapeutic interest. In this context, the ...
Segovia Laserna, Rosario (Date of defense: 2022-03-08)
After decades of exorbitant antibiotic misuse and overuse in human medicine, agriculture and livestock industry, multidrug resistant bacteria (MDR) have become a major medical concern. In this regard, ...
Arlegui Chamizo, Aitor (Date of defense: 2019-12-16)
La quiralidad es una propiedad fundamental de la naturaleza. La vida en la Tierra se basa en la quiralidad. Casi todos los compuestos quirales presentes en los organismos vivos se encuentran solo en una ...
Monlleó Mas, Ester (Date of defense: 2016-11-25)
Gaucher disease (GD) is one of the most prevalent lysosomal storage diseases.A mutation on gene gba1 generates a misfolded enzyme acid β-glucosidase. Due to this, this enzyme is not properly transported ...
Mohammad Jabeen, Irrem Laareb (Date of defense: 2021-09-23)
c-Src is a non-receptor tyrosine kinase that controls numerous cellular signaling pathways. c-Src implication in human cancers was brought into the attention in the 1980s. Since its discovery, ...