Castellá Giner, Moisés (Date of defense: 2023-09-29)
[emg] Alternative splicing (AS) is a gene expression regulatory mechanism that enables generation of multiple mRNA isoforms from a single gene which commonly are translated into proteins. This mechanism ...
Rossell Rusiñol, Joana (Date of defense: 2021-02-26)
An unbalanced, unhealthy diet is one of the main causes leading to obesity and the apparition of comorbidities. Bariatric surgery is currently the most effective and durable treatment against obesity. ...
Delgado Anglés, Alejandro (Date of defense: 2021-10-25)
Brown and beige adipose tissues are mediators of adaptive energy expenditure in mammals, in contrast with the energy storage role of white fat. Mitochondrial activity, including uncoupled respiration, ...
Mas Marin, Eduard (Date of defense: 2021-07-23)
Nucleoside transporters are essential for nucleotide homeostasis as well as for nucleoside-derived drugs bioavailability. Non-canonical natural nucleosides or “epigenetic nucleosides” are endogenously ...
Gallego Pérez, Diego (Date of defense: 2022-09-29)
Molecular dynamics (MD) simulations are the equivalent to a computational microscope allowing us to interrogate molecules and their behaviour in complex systems. They are recognised as a valuable and ...
Ferrer Curriu, Gemma (Date of defense: 2020-07-23)
Cardiovascular diseases are one of the leading causes of mortality in industrialized countries and are caused by genetic factors, environmental factors or comorbidities. This thesis is focused on three ...
Frager, Petra (Date of defense: 2022-10-28)
[eng] Decreased physical activity and increased consumption of energy-rich food are hallmark lifestyle modifications that developed and amplified over the course of only a few decades. These changes in ...
Núñez Carpintero, Iker (Date of defense: 2023-11-14)
[eng] The vast and continuously increasing volume of available biomedical data produced during the last decades opens new opportunities for large-scale modeling of disease biology, facilitating a more ...
Pérez Olives, Catalina (Date of defense: 2023-11-17)
[eng] Adenosine and endocannabinoids are regulatory molecules that are present in all organ and physiological systems. They act via specific receptors belonging to the G protein-coupled receptor (GPCR) ...
Estadella Pérez, Irene (Date of defense: 2023-01-20)
[eng] The voltage gated potassium channel Kv1.3 is a transmembrane protein that selectively drives potassium ions participating in the electrochemical gradient of cell membranes. This channel presents ...