Medrano Moya, Mireia (Date of defense: 2017-06-23)
La oligomerización es un proceso común en la biología de los receptores de membrana, compartida por los GPCRs. Los GPCRs constituyen aproximadamente un 45% de las dianas de los fármacos comercializados ...
Irazoqui Guimon, Andrea (Date of defense: 2021-12-03)
Some forms of mitochondrial dysfunction induce sterile inflammation through mitochondrial DNA (mtDNA) recognition by intracellular DNA sensors. However, our understanding of the processes operating this ...
Caviedes Cárdenas, Liska Rayen (Date of defense: 2018-10-22)
Nucleosides and nucleotides have a key role in cell physiology being implicated in crucial processes such as DNA and RNA synthesis, cell signaling and metabolic regulation. Purine and pyrimidine nucleotide ...
Tarragó Celada, Josep (Date of defense: 2020-09-16)
Metastasis is the main cause of cancer-related deaths and it is of great biomedical importance to develop new therapeutic strategies that specifically target metastatic cells. Therefore, a better ...
Viel Oliva, Albert (Date of defense: 2017-06-16)
Els nucleòsids són metabòlits imprescindibles per a la cèl·lula ja que són els precursors d’un gran nombre de biomolècules. Aquests nucleòsids poden ser sintetitzats per la cèl·lula o es poden recuperar ...
Casadó Anguera, Verònica (Date of defense: 2018-06-14)
Catecholamines, including dopamine (DA) and norepinephrine (NE), are widely distributed in the body and constitute a class of conventional neurotransmitters and hormones that occupy key positions in the ...
Serrano Albarrás, Antonio (Date of defense: 2018-11-23)
Ion channels are transmembrane proteins containing aqueous pores which, once open, permit the pass of ions through the plasma membrane. This ion flux takes places following the electrochemical gradient ...
Barros, Susana Raquel Costa (Date of defense: 2020-02-13)
OPA1 is a dynamin-related protein that is responsible for the fusion of the internal mitochondrial membrane and essential to control the morphology of the mitochondrial cristae. Thus, it directly impacts ...
Etayo Labiano, Iñigo Javier (Date of defense: 2018-05-15)
Los receptores de cannabinoides, CB1R y CB2R, que forman parte del sistema endocannabinoide, pertenecen a la superfamilia de receptores acoplados a proteína G (GPCR). El sistema endocannabinoide se ...
Sabaté Pérez, Alba (Date of defense: 2019-10-21)
Overweight and obesity have increased dramatically during recent decades becoming a major health problem for which therapeutic options are limited. Thus, there is an urgent need to develop new safe ...