Rupérez Gonzalo, Celia (Date of defense: 2020-09-10)
El objetivo principal de esta tesis fue el estudio de la función de dos nuevas cardiocinas, FGF21 y Metrnl, durante el desarrollo de la patología cardíaca. Se dividió en los siguientes apartados: PARTE ...
Sastre Martinez, Daniel (Date of defense: 2022-04-08)
Kv1.3 plays a crucial role in leukocytes, where it regulates activation and proliferation. In these cells, Kv1.3 is coexpressed with modulatory subunit KCNE4. This ancillary peptide acts as a dominant ...
Rodríguez Ruiz, Mar (Date of defense: 2018-09-10)
Los GPCRs son proteínas de membrana versátiles capaces de ser activadas por una amplia variedad de estímulos y son responsables de la transducción de señales extracelulares de manera específica. Regulan ...
Rodríguez Nuevo, Aida (Date of defense: 2018-04-12)
Opa1 is a mitochondrial dynamics protein responsible for the fusion of the inner mitochondrial membrane, the maintenance of cristae morphology, and involved in mitochondrial DNA stability. In this study ...
Casanovas Ferrero, Mireia (Date of defense: 2021-09-06)
Actualmente, entre el 30-40% de los medicamentos comercializados tienen como diana a un receptor acoplado a proteína G (GPCR). Además, la capacidad que tienen estos receptores para interaccionar físicamente ...
Zodda, Erika (Date of defense: 2019-12-13)
The endothelium plays a pivotal role in the development of cardiovascular disease (CVD) and emerging evidence indicates that pathological blood vessel responses and endothelial dysfunction are associated ...
Baptista, Inês do Carmo Viegas (Date of defense: 2022-04-07)
Leukaemia is one of the types of cancer where treatment resistance is prevalent. Better understanding of leukemic cells metabolism opens possibilities for new therapeutic strategies and better prognosis ...
Nukala, Sarath Babu (Date of defense: 2019-05-23)
The vascular endothelium is one of the major targets of oxidative stress, playing an important role in the development of vascular-related disorders, such as atherosclerotic disease1. Oxidative stress ...
Perelló-Reus, Catalina (Date of defense: 2020-06-02)
Maintenance of balanced nucleotide pools is necessary for cellular homeostasis. The nucleotide content of the cell is determined by the uptake of nucleosides by specific transporters, the salvage pathway ...
Foguet Coll, Carles (Date of defense: 2019-12-20)
Metabolism is a hallmark of life and underlies most biological processes in both health and disease. For instance, dysregulation of liver metabolism underlies multifactorial disorders such as diabetes ...