Royo Garrido, Romina (Date of defense: 2023-03-31)
[eng] Next-generation sequencing (NGS) has revolutionized biomedical sciences, especially in the area of cancer. It has nourished genomic research with extensive collections of sequenced genomes that ...
Irazoqui Guimon, Andrea (Date of defense: 2021-12-03)
Some forms of mitochondrial dysfunction induce sterile inflammation through mitochondrial DNA (mtDNA) recognition by intracellular DNA sensors. However, our understanding of the processes operating this ...
Contreras Mostazo, Miriam Guadalupe (Date of defense: 2020-10-21)
Cancer cells, including leukemic cells, can react to therapeutic treatment by altering their metabolic phenotype (“metabolic reprogramming”) to keep their accelerated proliferative state, eventually ...
Tarragó Celada, Josep (Date of defense: 2020-09-16)
Metastasis is the main cause of cancer-related deaths and it is of great biomedical importance to develop new therapeutic strategies that specifically target metastatic cells. Therefore, a better ...
Díaz Sáez, Francisco (Date of defense: 2021-02-12)
Neuregulin-4 has emerged as a novel adipokine in recent years. Several authors have previously explored the endocrine role of this adipocyte-secreted growth factor in the liver metabolism. In those ...
Barros, Susana Raquel Costa (Date of defense: 2020-02-13)
OPA1 is a dynamin-related protein that is responsible for the fusion of the internal mitochondrial membrane and essential to control the morphology of the mitochondrial cristae. Thus, it directly impacts ...
Sastre Martinez, Daniel (Date of defense: 2022-04-08)
Kv1.3 plays a crucial role in leukocytes, where it regulates activation and proliferation. In these cells, Kv1.3 is coexpressed with modulatory subunit KCNE4. This ancillary peptide acts as a dominant ...
Baptista, Inês do Carmo Viegas (Date of defense: 2022-04-07)
Leukaemia is one of the types of cancer where treatment resistance is prevalent. Better understanding of leukemic cells metabolism opens possibilities for new therapeutic strategies and better prognosis ...
Serrano Novillo, Clara (Date of defense: 2020-01-17)
Voltage gated K+ channels (Kv) are transmembrane proteins that allow the pass-thorugh of potassium ions, regulating the electrochemical gradient of the cell membrane. This way, they modulate several ...
Castellá Giner, Moisés (Date of defense: 2023-09-29)
[emg] Alternative splicing (AS) is a gene expression regulatory mechanism that enables generation of multiple mRNA isoforms from a single gene which commonly are translated into proteins. This mechanism ...