Boces Pascual, Clara (Date of defense: 2020-06-17)
Human Concentrative Nucleoside Transporters (hCNTs) are encoded by SLC28 gene family. It has been demonstrated that hCNT1 is lost in some cancers. Furthermore, hCNTs have the ability of translocating ...
Carmona Maurici, Júlia (Date of defense: 2022-10-14)
[cat] La predicció del risc de patir un esdeveniment cardiovascular en les persones amb obesitat severa és imprecisa. A més, els mecanismes que interrelacionen l’obesitat amb l’ateroesclerosi no es ...
Morón Ros, Samantha (Date of defense: 2020-11-09)
[spa] El objetivo de la presente tesis se basa en establecer, mediante el uso de modelos experimentales animales y celulares, cuál es el papel de la enterocina FGF15/19: a) en la adiposidad y ...
Castellanos Martínez, Antonio (Date of defense: 2021-03-22)
En la enfermedad de Huntington (HD), muchos síntomas están asociados con alteraciones en las funciones reguladas por la dopamina y el glutamato; una intervención directa sobre los receptores de dopamina ...
Rivas Santisteban, Rafael (Date of defense: 2021-10-15)
Los receptores acoplados a proteína G o GPCRs conforman la mayor familia de receptores de membrana celular en organismos eucariotas. En humanos se han descrito más de 800 GPCRs, gran parte de ellos ...
Royo Garrido, Romina (Date of defense: 2023-03-31)
[eng] Next-generation sequencing (NGS) has revolutionized biomedical sciences, especially in the area of cancer. It has nourished genomic research with extensive collections of sequenced genomes that ...
Irazoqui Guimon, Andrea (Date of defense: 2021-12-03)
Some forms of mitochondrial dysfunction induce sterile inflammation through mitochondrial DNA (mtDNA) recognition by intracellular DNA sensors. However, our understanding of the processes operating this ...
Contreras Mostazo, Miriam Guadalupe (Date of defense: 2020-10-21)
Cancer cells, including leukemic cells, can react to therapeutic treatment by altering their metabolic phenotype (“metabolic reprogramming”) to keep their accelerated proliferative state, eventually ...
Tarragó Celada, Josep (Date of defense: 2020-09-16)
Metastasis is the main cause of cancer-related deaths and it is of great biomedical importance to develop new therapeutic strategies that specifically target metastatic cells. Therefore, a better ...
Díaz Sáez, Francisco (Date of defense: 2021-02-12)
Neuregulin-4 has emerged as a novel adipokine in recent years. Several authors have previously explored the endocrine role of this adipocyte-secreted growth factor in the liver metabolism. In those ...