Envíos recientes

Clasificación automática de malaria e inclusiones eritrocitarias anómalas en sangre periférica utilizando modelos de machine learning 

Molina Borrás, Angel (Fecha de defensa: 2025-03-03)

[spa] Los especialistas de laboratorio juegan un papel esencial en el diagnóstico del paludismo mediante la identificación de características morfológicas cualitativas de los hematíes en la revisión del frotis de sangre ...

Muscle dysfunction and exercised-based rehabilitation in cardiac diseases: From muscular physiology in animals to prognosis impact on patients 

Cabrera-Aguilera, Ignacio Alfredo (Fecha de defensa: 2023-01-24)

[eng] Cardiovascular diseases (CVD) such heart failure (HF) or acute coronary syndrome (ACS) impairs muscular dysfunction that affect cardiorespiratory fitness. Animals models realistically mimicking CVD, including the ...

Depletion of aneuploid cells in epithelial tissues is shaped by cell-to-cell interactions 

Fusari, Elena (Fecha de defensa: 2025-04-04)

[eng] Aneuploidy, the major cause of miscarriages, is pervasive in early human embryos, and later in life, it correlates with pathological conditions including cancer and other ageing-related conditions. At the cellular ...

Implications of astrocytic RTP801 in neuroinflammation and neurodegeneration in Alzheimer’s disease 

Chicote González, Almudena (Fecha de defensa: 2024-11-29)

[eng] The central nervous system (CNS), consisting of the brain and spinal cord, is supported by various cells including neurons, glial cells, and blood vessel cells. Neurons are responsible for transmitting signals, while ...

Exploring extracellular small RNAs as potential early biomarkers and mediators in the pathogenesis of Huntington’s disease 

Herrero Lorenzo, Marina (Fecha de defensa: 2024-10-18)

[eng] Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by an expansion of CAG triplets in the huntingtin gene (HTT). The main neuropathological signs of HD include the presence of ...

Investigating therapeutic targeting to intercellular adhesion molecule 1 through epitope, isoform, and cross-reactivity selection 

Vigo, Marco (Fecha de defensa: 2024-09-26)

[eng] AIM AND HYPOTHESIS: Based on the previous literature and indicated gaps of knowledge, the hypothesis for this study was that by generating cell lines expressing only specific forms of ICAM-1, it may be possible to ...

Nous abordatges en l'estudi de les malalties autoimmunitàries 

Pérez Isidro, Albert (Fecha de defensa: 2024-10-30)

[cat] HIPÒTESIS: Un augment del nombre de biomarcadors disponibles amplia la informació a l’abast del clínic i ajuda a una millor la presa de decisions mèdiques i terapèutiques per a l’atenció dels pacients amb malalties ...

RTP801: a novel regulator of the tRNA ligase complex in Alzheimer's disease 

Campoy Campos, Genís (Fecha de defensa: 2024-06-19)

[eng] RTP801/REDD1 is a stress-responsive protein overexpressed in neurodegenerative diseases such as Alzheimer’s disease (AD) that contributes to cognitive deficits and neuroinflammation. Here we found that RTP801 interacts ...

Inhibition of KRAS oncogenic activity by interfering with new KRAS interactors 

Abuasaker, Baraa (Fecha de defensa: 2024-06-14)

[eng] INTRODUCTION: The Kirsten rat sarcoma oncogene (KRAS) homologue stands out as a prominent oncogene, distinguished by its notably elevated mutation rate compared to other oncogenes. This genetic anomaly is intricately ...

Machine Learning for predicting Immunotherapy response from routine Medical Imaging 

Ligero Hernández, Marta (Fecha de defensa: 2024-03-15)

[eng] HYPOTHESIS: Precision oncology has revolutionized the landscape of cancer treatment. Emerging therapeu- tic approaches, such as immunotherapy or anti-angiogenic agents, have exhibited remarkable outcomes in solid ...

Regulación de la separasa mediada por el nuevo papel de Sak1 en mitosis 

Vaquero Pelaz, David (Fecha de defensa: 2024-02-02)

[spa] El ciclo celular es un conjunto ordenado de sucesos que tienen como fin el crecimiento de una célula y su división en dos células hijas. Uno de los sucesos más relevantes en el ciclo celular es la correcta segregación ...

Molecular contents and functional characterization of extracellular vesicles in plasma of Alzheimer’s disease patients: analysis in response to the AMBAR treatment 

Solaguren-Beascoa Negre, Maria (Fecha de defensa: 2024-02-02)

[eng] The hypothesis underlying the AMBAR study research seeks to evaluate the clinical efficacy of PE, in combination with albumin and intravenous immunoglobulin replacement (IVIG), as a treatment for Alzheimer's disease ...

Role of polyreactive autoantibodies in the physiopathology of Sjögren’s Syndrome 

Gutiérrez Cózar, Rebeca (Fecha de defensa: 2024-01-22)

[eng] Sjögren's syndrome (SjS) is a chronic autoimmune disease that mainly affects the exocrine glands and is characterized by the presence of antinuclear antibodies such as anti-Ro52 and anti-dsDNA. Our previous analysis ...

Evaluación funcional del péptido EAR-20 como posible agonista de los receptores ionotrópicos de glutamato de tipo NMDA 

García Díaz, Roberto (Fecha de defensa: 2023-05-26)

[spa] Debido a la importancia de la modulación del NMDAR, en el grupo de investigación de proteínas (GRIP) se han diseñado una serie de péptidos derivados de la Conantokina-G (Con-G), un péptido antagonista de los NMDARs, ...

Noves estratègies terapèutiques contra la resposta a l’estrès replicatiu en el càncer colorectal 

Unzueta Payeras, Fernando (Fecha de defensa: 2023-07-28)

[cat] El nostre laboratori està centrat en l’estudi de la resposta a l’estrès replicatiu, ja que aquest estrès està relacionat amb la tumorigènesi i la seva resposta és un mecanisme fonamental per preservar l’estabilitat ...

Comparative study of nanocarriers targeted to different transport pathways into and across the endothelium for brain delivery of therapeutic enzymes 

Loeck, Maximilian (Fecha de defensa: 2022-09-16)

[eng] The blood-brain barrier (BBB) is a major obstacle for the treatment of neurological diseases such as common Parkinson’s disease or rare lysosomal storage disorders (LSDs). LSDs are characterised by deficiency of ...

Mitochondrial dynamics and quality control mechanisms in Huntington's disease 

López Molina, Laura (Fecha de defensa: 2022-06-17)

[spa] La enfermedad de Huntington (EH) es una enfermedad neurodegenerativa hereditaria causada por la mutación de la huntingtina (mHtt) que ocasiona síntomas motores, cognitivos y psiquiátricos. La característica ...

New insights into ionotropic glutamate receptors in physiological and pathological conditions 

Miguez Cabello, Federico (Fecha de defensa: 2021-02-09)

[eng] Speaking metaphorically, the human nervous system is a complex ensemble of millions of parts operating together one with another. For this reason, each part is fundamental for the correct function of the whole system. ...

Mecanismes neuronals de la picor aguda i crònica en neurones sensorials: implicació del canal TRESK 

Andrés Bilbé, Alba (Fecha de defensa: 2020-11-13)

[cat] TRESK (K2P18.1) és un canal de potassi de fuga que s’expressa en algunes subpoblacions de neurones sensorials, on modula el potencial de membrana en repòs, la descàrrega de potencial d’acció i l’excitabilitat neuronal. ...

Effects of human serum albumin on TNFα-induced cell death and mitochondrial dysfunction in the liver cells 

Duran Güell, Marta (Fecha de defensa: 2023-04-12)

[eng] Albumin exerts pleiotropic actions beyond its oncotic power, which include binding, transport and detoxification of endogenous and exogenous molecules, antioxidant activity and the modulation of immune and inflammatory ...