Mostrando ítems 11-18 de 18
Banjer, Hamsa Jameel (Fecha de defensa: 2018-07-06)
Transportome alterations have been associated with oncogenesis. The loss of human Concentrative Nucleoside Transporter 1 (hCNT1) during carcinogenesis seems to be a relatively common event in tumors and ...
Segura Bayona, Sandra (Fecha de defensa: 2018-06-22)
Histone deposition during DNA replication, transcription and repair ensures the faithful maintenance of genetic and epigenetic information. The histone H3-H4 chaperone ASF1 participates in both replication ...
Raimondi, Giulia (Fecha de defensa: 2020-06-08)
The general goal of this thesis has been to progress oncolytic adenovirus therapy for PDAC, by the incorporation of novel preclinical models to test for patient-specific responses and the generation of ...
Sallaberry Pinto, Júlia (Fecha de defensa: 2019-03-22)
Local invasion is a key cell-biological event in the metastatic cascade. In response to a changing microenvironment, cancer cells may act using two main strategies of invasion: single cell invasion and ...
Cristóbal Valero, Helena (Fecha de defensa: 2022-06-08)
La familia TAM consta de tres receptores de membrana de tipo tirosina-quinasa: TYRO3, AXL, MERTK. Sus ligandos son Growth Arrest-Specific 6 (GAS6) y la Proteína S (PROS1). Éstas últimas son proteínas ...
Núñez Manchón, Estela (Fecha de defensa: 2020-07-16)
La viroterapia oncolítica es un tratamiento emergente basado en el uso de virus replicativos que de manera selectiva infectan células tumorales y provocan su muerte. Hasta la fecha, se han producido ...
Figueiredo, Ana Raquel Martins (Fecha de defensa: 2017-06-09)
Pericytes (PCs) are important regulators of the vascular development promoting vessel growth and stabilization. They have recently emerged as a therapeutic target to promote or inhibit angiogenesis. ...
Lewis, Michael (Fecha de defensa: 2022-11-11)
[eng] Transcriptional regulation is a multifaceted and fundamental process, which underpins normal physiology, and its dysregulation is associated to numerous pathologies. Using two inherently different ...