Vilaplana Saiz, Marta (Date of defense: 2021-01-22)
This thesis shows the research carried out on two specific diseases: familial hypercholesterolemia, which is included within the cardiovascular diseases group, and cancer. These diseases are the major ...
Petrillo, Giovanna (Date of defense: 2017-06-28)
The rapid progress in structural and molecular biology over the past fifteen years has allowed chemists to access the structures of enzymes, of their complexes and of engineered variants. This wealth ...
Yoldi, Guillermo (Date of defense: 2018-10-23)
The discovery that RANK signaling mediates the protumorigenic role of progesterone in the mammary gland and its association with poor prognosis in breast cancer has opened the possibility of using RANKL ...
Rosell Oliveras, Mireia (Date of defense: 2020-12-21)
The study of the 3D structural details of protein interactions is essential to understand biomolecular functions at the molecular level. In this context, the limited availability of experimental structures ...
Nicolàs i Aragó, Adrià (Date of defense: 2022-12-14)
[eng] L-type amino acid transporters play key roles in human physiology and are involved in several human pathologies such as primary inherited aminoacidurias (Feliubadaló et al., 1999; Torrents et al., ...
González Velasco, Lorena (Date of defense: 2021-09-14)
Non-canonical activation of p38α MAPK has been associated to cardiomyocyte death in several cardiovascular pathologies, such as myocardial ischaemia-reper- fusion injury. Unfortunately, current p38α ...
García Lema, Jorge (Date of defense: 2020-10-08)
Adenosine deaminase acting on tRNAs (ADAT) is a eukaryotic heterodimer, composed by ADAT2 and ADAT3, that catalyses the deamination of adenosine-to-inosine in the anticodon loop of tRNAs. ADAT proteins ...
Sanchis Villariz, Ana (Date of defense: 2018-07-25)
The central topic of this thesis has been the study, development and validation of diverse multiplexed diagnostics platforms and techniques that can be applied to a wide range of topics, from environmental ...
Garcia Puig, Anna (Date of defense: 2019-03-22)
Adult zebrafish (Danio rerio), in contrast to mammals, are able to regenerate their hearts in response to injury or experimental amputation. Our understanding of the cellular and molecular bases that ...
Urdiroz Urricelqui, Uxue (Date of defense: 2022-04-07)
El papel que juega el metabolismo lipídico en la progresión del cáncer está siendo revisado. Estudios recientes de nuestro laboratorio demuestran que el tratamiento con ácido palmítico (AP) de ...