Domostegui Fernández, Ana (Date of defense: 2019-12-05)
The oncogene MYC is altered and its expression is deregulated in up to 70% of human cancers, including B cell neoplasms. Earlier studies in a mouse model of Eμ-MYC-driven B-cell lymphomas reported that ...
Garza Puentes, Andrea de la (Date of defense: 2017-09-28)
Maternal obesity has implications on the health of future generations by early life programming. The mother is usually the main source of nutrients for the fetus and neonate, hence her nutritional status ...
Méndiz Manero, Mª Victoria (Date of defense: 2022-09-16)
[eng] I have used the brain tumours that originate in Drosophila larvae upon depletion of the brain tumor (brat) gene as a model to study neoplastic malignant growth. I have used genetic analysis to ...
Tatarski, Miloš (Date of defense: 2018-09-21)
INTRODUCTION: For decades it was known that many species contain embryo specific linker histone H1 variants that replace the somatic H1 during early embryogenesis. This is especially important because ...
Vázquez Lozano, Javier (Date of defense: 2019-09-13)
Three-dimensional ligand-based virtual screening methods have been used for many years in drug discovery, with a variable success depending on different factors, such as the complexity of the target ...
Suñé Pou, Marc (Date of defense: 2019-07-12)
Cationic Solid Lipid Nanoparticles (cSLNs) are one of the most promising nonviral vectors for gene therapy and DNA / RNA delivery. The aim of this thesis is the development and research of new formulations ...
Arias Badia, Marcel (Date of defense: 2017-09-29)
Oncolytic virotherapy with Adenoviruses has regained importance in the past years with the appearance of fresh and promising strategies to deal with tumors. Among the major limitations of this therapy ...
Calle Fabregat, Carlos de la (Date of defense: 2022-03-15)
OBJECTIVE: Identifying predictive biomarkers at early stages of undifferentiated arthritis (UA) is crucial for starting appropriate therapies to avoid poor outcomes. Monocytes and macrophages, largely ...
Atanasov, Kostadin Evgeniev (Date of defense: 2019-05-14)
Arabidopsis thaliana is a small ruderal weed with prominent north-hemisphere distribution. It has an autogamous style of reproduction, whereas about 3% of the natural population can exhibit outcrosses. ...
Rodriguez Urretavizcaya, Bárbara (Date of defense: 2022-03-25)
Infectious diseases are still one of the main leading causes of death worldwide mainly due the overuse and the lack of development of new antibiotics. This fact has increased the appearance of multidrug ...