Burguera Hernández, Demian (Date of defense: 2017-09-22)
In the present work, we studied the evolution of alternative splicing (AS) from different perspectives. First, we performed a preliminary analysis where we identified alternative exons with tissue-specific ...
Abad Morales, Víctor (Date of defense: 2017-02-03)
La sumoïlació és una modificació posttraduccional (PTM) que consisteix en la conjugació covalent i reversible d’una proteïna SUMO (Small ubiquitin-like modifier) al residu lisina d’una proteïna diana. ...
Cornet Bartolomé, David (Date of defense: 2019-07-09)
Infertility, defined by the World Health Organization (WHO) as the inability to conceive after a year of unprotected sex, is a disease that affects 1 in 9 couples of reproductive age worldwide. Most of ...
Gómez Llonin, Andrea (Date of defense: 2021-04-30)
The application of NGS techniques to the study of mature B-cell neoplasms at the research level is providing a large amount of new information, in certain cases with clinical implications, which includes ...
Benítez Álvarez, Lisandra (Date of defense: 2022-06-16)
Evolutionary Biology offers a set of methods and theories to elucidate the evolutionary processes that lead to the diversification of life. With the development of sequencing technologies, the access ...
Escuer Pifarré, Paula (Date of defense: 2022-12-21)
[eng] During the last decade, advances in high-throughput sequencing (HTS) technologies have increased exponentially the generation of genomic data, especially of non-model species. In this thesis, we ...
Pino, V. Beatriz (Date of defense: 2022-07-15)
In the Drosophila larva, most of the juvenile tissues are made up of large polyploid cells fated to die during metamorphosis stage. The dorsal trunk of the tracheal system is composed mainly of these ...
Pascual Alonso, Ainhoa (Date of defense: 2023-07-14)
[eng] MECP2 is a multifunctional gene involved in multiple processes such as transcription regulation, chromatin remodelling, splicing and miRNA regulation. Malfunction of MECP2 due to loss of function ...
Valdés Gutiérrez, Antonio (Date of defense: 2019-03-01)
La mayoría de las transacciones del genoma producen estrés topológico en el ADN, que se reduce gracias a la acción de las topoisomerasas. Por ejemplo, durante la transcripción y replicación del ADN, las ...
Leria Florensa, Laia (Date of defense: 2019-10-28)
The main goal of the present thesis has been to shed light into the processes that shape the genetic diversity of organisms, focussing in the following factors: the type of reproduction, the morphological ...