Seguridad y eficacia de varnimcabtagene autoleucel (ARI-0001) en síndromes linfoproliferativos CD19 positivos 

    Ortiz-Maldonado Gibson, Valentín (Fecha de defensa: 2022-10-26)

    [spa] En términos generales, el pronóstico de los síndromes linfoproliferativos originados en el linfocito B es francamente desfavorable una vez estos recaen o son refractarios (R/R) a la primera o posteriores líneas de ...

    Seqüeles dentals en adolescents sotmesos a tractament oncològic durant la primera infància 

    Rabassa Blanco, Judit (Fecha de defensa: 2022-12-16)

    [cat] El càncer infantil és una de les principals causes de mortalitat durant la infància i l’adolescència. Segons l’Associació Espanyola contra el càncer, 1500 nens/es de 0 a 14 anys són diagnosticats anualment d’aquesta ...

    Sleep-Disordered Breathing in Children with Cleft Palate 

    Moraleda Cibrián, Marta (Fecha de defensa: 2022-07-11)

    [eng] INTRODUCTION: One in 700 newborns in the United States is born with cleft palate every year. It is estimated that the prevalence of sleep-disordered breathing symptoms in children with cleft palate, compared with ...

    Social determinants of major depressive disorder. Exploring the interplay of age, loneliness, and the COVID-19 pandemic 

    Gabarrell Pascuet, Aina (Fecha de defensa: 2024-05-24)

    [eng] INTRODUCTION: Depression is a highly prevalent condition, recognized as one of the leading causes of years lived with disability worldwide. Its global prevalence continues to rise, with major depressive disorder ...

    Spatial learning in the network of hippocampal place cells: Altering memory using a mouse model of passive transfer of antibodies from patients with anti-NMDAR encephalitis 

    Zamani Mozafarabadi, AmirPasha (Fecha de defensa: 2022-12-16)

    [eng] Anti-NMDAR encephalitis is the most frequent antibody-mediated encephalitis known to date, in which patients develop specific antibodies directed against the N-methyl-D-aspartate receptors (NMDARs) in the central ...

    Spatiotemporal dynamics of the cerebral cortex: from unconscious brain states towards consciousness 

    Camassa, Alessandra (Fecha de defensa: 2021-07-23)

    Understanding the dynamics of the brain that gives rise to conscious experience and that underscore the transition through different brain states is one of the central problems of today’s neuroscience. The cerebral cortex ...

    Spontaneous and perturbation-based electroencephalographic markers of brain health 

    Perellón Alfonso, Ruben (Fecha de defensa: 2024-03-22)

    [eng] INTRODUCTION: Brain health is the optimal state of brain functioning that allows the individual to reach their maximum potential throughout life, regardless of the presence or absence of diseases. In order to promote ...

    Study of collective cell durotaxis as an active wetting phenomenon 

    Pallares Pallares, Macià Esteve (Fecha de defensa: 2022-03-08)

    Cell migration is essential to many biological processes. In adult organisms, it is crucial for wound healing, homeostasis, and immune response, whereas aberrant cell migration potentially leads to pathology. For example, ...

    Study of the role of cell-matrix force transmission in naive to primed pluripotency transition in mouse embryonic stem cells 

    Viswandha Venkata Naga Sai, Srivatsava (Fecha de defensa: 2024-03-07)

    [eng] “Doing the right thing, at the right time, to the right extent, in the right manner, and for the right purpose”. This isn’t a shoddy attempt at virtue signalling by invoking Aristotle. It rather is my philosophical ...

    Susceptibilidad a la infección por SARS-CoV-2 en la población pediátrica y su contribución en la transmisión dentro de los núcleos familiares 

    Melé Casas, Maria (Fecha de defensa: 2024-05-02)

    [spa] El presente proyecto de investigación se sitúa en el contexto pre-variantes (variante Wuhan), momento en el que la susceptibilidad de los niños a la infección por SARS-CoV- 2 era aún incierta. Tampoco se conocía ...

    Synaptic and circuit mechanisms of working memory and their dysfunction in anti-NMDA receptor encephalitis and schizophrenia 

    Stein, Heike (Fecha de defensa: 2020-11-13)

    [eng] In this thesis, I investigate different synaptic and circuit mechanisms of working memory, how their interaction produces specific working memory biases, and how their disruption in psychiatric or neurological disease ...

    The implementation of Advanced Practice Nursing in Catalonia 

    Sevilla Guerra, Sonia (Fecha de defensa: 2018-06-01)

    INTRODUCTION: The expansion of professional roles has been proved to be an innovative solution across some countries in order to help address healthcare integration, coordination, continuity, access and health care ...

    The new bioactive hydraulic sealers in endodontics 

    Bardini, Giulia (Fecha de defensa: 2022-11-30)

    [eng] INTRODUCTION: In the last twenty years, sealing cements based on tricalcium silicate cements have been introduced into the market for orthograde filling of the root canal system. These silicate-based sealing cements ...

    The role of genome architecture in normal and neoplastic B cells: a multi-omics approach 

    Vilarrasa Blasi, Roser (Fecha de defensa: 2020-10-09)

    [eng] Nuclear organization and its impact on gene regulation have started to be elucidated thanks to the development of chromosomal conformation capture techniques. In this doctoral thesis, in situ Hi-C data and nine ...

    Three-dimensional evaluation of the effect of therapeutic orthodontic premolar extraction using digital dental models. A Retrospective Study 

    Abohabib, Ahmed Mohamed Saad (Fecha de defensa: 2024-05-23)

    [eng] INTRODUCTION: Orthodontic premolar extraction for therapeutic purposes is a widely used orthodontic procedure; however, there is still ongoing investigation into its effects on the dimensions of the upper teeth ...

    El tipo de donante, la hemoglobina basal y la amplitud máxima del coágulo del tromboelastograma basal: cofactores determinantes de la transfusión de concentrados de hematíes en el trasplante hepático 

    Viguera Fernández, Laura (Fecha de defensa: 2022-11-15)

    [spa] La primera hipótesis de esta tesis doctoral, establece que la hemoglobina basal (previa al trasplante hepático) y la amplitud máxima del coagulo del tromboelastograma, pueden predecir la transfusión intraoperatoria ...

    Tomografía por Emisión de Positrones cuantificada en la evaluación prequirúrgica de la epilepsia 

    Mayoral Peñalva, Maria (Fecha de defensa: 2019-07-24)

    La epilepsia es una enfermedad con una elevada prevalencia e impacto sociosanitario. Aproximadamente un tercio de los pacientes son resistentes al tratamiento farmacológico y en estos casos debe considerarse la cirugía ...

    Towards Novel Therapeutical Strategies for NUT Carcinoma 

    Escudero Iriarte, Carmen (Fecha de defensa: 2024-06-07)

    [eng] NUT Carcinoma (NC) is a rare and aggressive cancer lacking effective treatment, with a dismal prognosis of less than seven months after diagnosis. It is characterized by chromosomal rearrangements that involve the ...

    Towards precision medicine in pediatric liver cancer: discovery and validation of prognostic biomarkers 

    Carrillo Reixach, Juan (Fecha de defensa: 2022-12-19)

    [eng] Pediatric liver cancer is considered a rare disease and represents <3% of all pediatric tumors worldwide. The main types of liver tumors in the pediatric age group are hepatoblastoma (HB) and hepatocellular carcinoma ...

    Tracking preformed serological and T-cell alloimmune memory together with donor/recipient Molecular Human Leukocyte Antigen (HLA) disparity to improve immune-risk stratification in Kidney Transplantation 

    Meneghini, Maria Antonia Emilia (Fecha de defensa: 2021-10-21)

    INTRODUCTION: The presence of a donor-specific alloimmune response negatively impacts allograft outcomes, being associated to risk of rejection and premature graft loss. Alloimmunity can be both preformed (memory) or can ...