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Facultat de Medicina i Ciències de la Salut: Recent submissions

Now showing items 21-40 of 547

    Psiquiatría nutricional aplicada al trastorno bipolar 

    Costa, Susana Patrícia Gomes da (Date of defense: 2024-12-18)

    [spa] INTRODUCCIÓN: El trastorno bipolar (TB) es un trastorno crónico del estado de ánimo caracterizado por fluctuaciones del estado de ánimo, que afecta a un amplio rango de población y se relaciona con un importante ...

    Valoración de la reserva ovárica. Estudio de parámetros hormonales y ecográficos 

    Peralta Flores, Sara (Date of defense: 2024-12-17)

    [spa] INTRODUCCIÓN: Los marcadores de reserva ovárica son excelentes predictores de respuesta ovárica, pronóstico y riesgo de complicaciones en FIV/ICSI, aunque no son predictores de fertilidad natural. La determinación ...

    Advancing precision medicine in cancer and COVID-19 with bioinformatics: a multifaceted affair 

    García Prieto, Carlos Antonio (Date of defense: 2024-12-14)

    [eng] Advancing precision medicine requires integrating bioinformatics to unravel complex biological data and translate these insights into clinical applications. This thesis explores the role of bioinformatics in enhancing ...

    Sleep disorders in immune-mediated synaptic encephalopathies 

    Muñoz Lopetegi, Amaia (Date of defense: 2024-12-17)

    [eng] INTRODUCTION: Autoimmune encephalitis (AEI) is an inflammatory disease of the central nervous system, caused by specific antibodies against synaptic or neural surface proteins. More than twenty have been described ...

    Unveiling the role of the Mediator complex in Ewing sarcoma tumorigenesis 

    Cuervas Oliveras, Irene (Date of defense: 2024-12-17)

    [eng] Ewing sarcoma is an aggressive tumor arising in bones and soft tissues that affects children and young adults. This disease is determined by an aberrant chromosomal translocation that forms an oncogenic fusion protein, ...

    Eficacia y seguridad de las nuevas técnicas de resección endoscópica para neoplasias precoces gastrointestinales 

    Uchima Koecklin, Hugo Ikuo (Date of defense: 2024-12-17)

    [spa] INTRODUCCIÓN: La detección y caracterización endoscópica de lesiones neoplásicas precoces (lesiones superficiales confinadas a la mucosa o submucosa que en casos seleccionados tienen un riesgo muy bajo de metástasis ...

    IKKα modulates metastatic activity by preventing Tight Junctions stabilization and collective cell migration 

    Alvarez Villanueva, Daniel (Date of defense: 2024-12-16)

    [eng] The IKKα kinase was previously found to activate multiple oncogenic and therapy-resistance pathways, including ATM/DDR, BRD4, and JAK/STAT3, independently of canonical NF-KB signaling. Here, we show that suppression ...

    New therapeutic approaches to target myofibroblast activation in liver pathologies: fibrosis and cholangiocarcinoma 

    Amengual Segura, Josep (Date of defense: 2024-12-16)

    [eng] HYPOTHESES: Iron accumulation and senescence mediate fibrosis progression in kidney and lung. In the liver, iron overload, specifically in hepatocytes, has been linked to hepatic diseases such as hereditary ...

    Diagnóstico de la causa de muerte y caracterización de infecciones fatales en muestras post mortem en países de baja renta 

    Hurtado Negreiros, Juan Carlos (Date of defense: 2024-12-13)

    [spa] INTRODUCCIÓN: La ausencia de datos confiables sobre las causas de muerte se ha señalado como un factor limitante para reducir la mortalidad en el mundo. Entendemos que para poder desarrollar un planteamiento y ...

    Understanding Adiposity through Body Shape Phenotypes: Implications for Cancer Risk, Inflammation, and Prediction 

    Peruchet Noray, Laia (Date of defense: 2024-12-13)

    [eng] INTRODUCTION. Obesity is characterized by excess body fat (adiposity) and is a major determinant of disability. Obesity is mainly measured by body mass index (BMI) although it presents several limitations. For instance, ...

    Unraveling the molecular basis of the metastatic process in Ewing sarcoma: insights into the role of LOXHD1 and PARP14 

    Sánchez Serra, Sara (Date of defense: 2024-12-13)

    [eng] HYPOTHESIS AND OBJECTIVES 1. Hypothesis: Metastasis is the worst prognostic factor in EwS patients, dropping patients’ overall survival to less than 30 %43. Further, about 25 % of patients present with metastatic ...

    Evaluación de factores de riesgo de retrombosis y sangrado en pacientes con enfermedad tromboembólica venosa 

    Gabara Xancó, Cristina (Date of defense: 2024-12-13)

    [spa] HIPÓTESIS: 1. Establecer las ratios de recurrencia, sangrado mayor, y las tasas de mortalidad tras un primer episodio de trombosis no provocada, puede ayudar en la decisión de mantener o suspender la anticoagulación ...

    Brain mechanisms and psychological determinants of mental health resilience. Learning from the COVID-19 pandemic 

    Cabello Toscano, María del Rocío (Date of defense: 2023-11-06)

    [eng] When confronted with a stressful situation, our reactions can vary greatly. In general, the population comes across to be resilient, being able to resist or adapt to disturbances. However, this is not the case for ...

    Radioterapia estereotáctica en lesiones óseas. Factor tiempo como predictor de supervivencia 

    Pérez Montero, Héctor (Date of defense: 2023-06-22)

    [spa] INTRODUCCIÓN: En los últimos años se ha producido una mejora en el pronóstico de los pacientes metastásicos gracias a los avances en terapias oncológicas. Debido a ello, el abordaje radical de las metástasis ha ido ...

    Generation of high-performance cellular model for Huntington’s disease 

    Lam, Lam (Date of defense: 2024-12-13)

    [eng] Huntington’s disease (HD) is an autosomal dominant inherited neurological disease, which is caused by mutation in the HTT gene that encodes for the huntingtin protein. The disease leads to involuntary movements, ...

    ZeGRIN: Using zebrafish GRIN-related disorders models for disease understanding and therapeutic discovery 

    Locubiche Serra, Sílvia (Date of defense: 2024-12-13)

    [eng] The glutamatergic neurotransmission system is crucial for brain function, and its dysregulation is involved in several neurological diseases, including developmental, psychiatric and neurodegenerative disorders. ...

    Impacto clínico y biológico de los trastornos respiratorios del sueño en la fibrosis pulmonar idiopática 

    Bordas Martínez, Jaume (Date of defense: 2024-12-12)

    [spa] INTRODUCCIÓN: Los pacientes con fibrosis pulmonar idiopática (FPI) presentan un elevado número de comorbilidades que pueden impactar en su calidad de vida y pronóstico. Entre ellas, los trastornos respiratorios ...

    Análisis de los incidentes con múltiples afectados intencionados en el Siglo XXI 

    Valiño Otero, Eva María (Date of defense: 2024-12-12)

    [spa] INTRODUCCIÓN: Los incidentes con múltiples afectados intencionados (IMAi), la mayoría clasificados como actos terroristas, son sucesos provocados por uno o más agresores activos con intención de originar el mayor ...

    Polycystic ovary syndrome in adolescent girls: treatment oriented to pathophysiology and new markers of effciacy 

    García Beltran, Cristina (Date of defense: 2024-12-12)

    [eng] Polycystic ovary syndrome (PCOS) could begin with a mismatch between prenatal (reduced) and postnatal (increased) growth, causing an excess of hepato-visceral fat. Dysfunction of adipose tissue, alteration of the ...

    Study of biofunctionalized titanium implants on an osteoporotic animal model 

    Alfaiate, David (Date of defense: 2024-12-11)

    [eng] INTRODUCTION: Titanium-based medical devices for bone implantation are currently considered the standard treatment when favorable health, repair and healing conditions are observed. Dental implants, joint prostheses, ...