Ancestral roles of IĸB proteins in Caenorhabditis elegans

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Universitat de Barcelona. Facultat de Medicina
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Ahumada Brena, David Ricardo
dc.date.accessioned
2023-07-17T06:32:03Z
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2023-07-17T06:32:03Z
dc.date.issued
2021-07-09
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http://hdl.handle.net/10803/688664
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Programa de Doctorat en Biomedicina / Tesi realitzada a l'Institut de Investigació Biomèdica de Bellvitge (IDIBELL)
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dc.description.abstract
[eng] Mammalian Inhibitor-of-kappa-B (IκBs) proteins exert their main function as negative regulators of NF-κB, a central signaling pathway controlling immunity and inflammation. An alternative chromatin role for IκBs has been shown to affect stemness and cell differentiation. However, the involvement of NF-κB in this function has not been excluded. NFKI-1 and IKB1 are IκB homologs in aenorhabditis elegans, which lacks NF-κB nuclear effectors. We found that nfki-1 and ikb-1 mutants display developmental defects that phenocopy mutations in Polycomb and UTX-1 histone demethylase, suggesting a role for C. elegans IκBs in chromatin regulation. Further supporting this possibility (i) we detected NFKI-1 in the nucleus of cells; (ii) NFKI-1 and IKB-1 bind to histones and Polycomb proteins, (iii) and associate with chromatin in vivo, and (iv) mutations in nfki-1 and ikb-1 alter chromatin marks. Based on these results, we propose that ancestral IκB proteins modulate chromatin marks with an impact on development.
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dc.format.extent
257 p.
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dc.language.iso
eng
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dc.publisher
Universitat de Barcelona
dc.rights.license
L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by/4.0/
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dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
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dc.source
TDX (Tesis Doctorals en Xarxa)
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Epigenètica
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Epigenética
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Epigenetics
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Càncer
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Cáncer
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Cancer
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Proteïnes supressores de tumors
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Proteinas supresoras de tumores
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Tumor suppressor protein
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Models animals en la investigació
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Modelos animales en investigación
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Animal models in research
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Ciències de la Salut
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dc.title
Ancestral roles of IĸB proteins in Caenorhabditis elegans
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dc.type
info:eu-repo/semantics/doctoralThesis
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info:eu-repo/semantics/publishedVersion
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616
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dc.contributor.director
Cerón Madrigal, Julián
dc.embargo.terms
cap
ca
dc.rights.accessLevel
info:eu-repo/semantics/openAccess


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