Recent Submissions

Immune Diversity: Phenotypic, Transcriptional, and Immunogenetic Insights into Normal and Neoplastic Lymphoid Cells 

Rashmi, Sonal (Date of defense: 2025-06-05)

El funcionamiento del sistema inmunológico se basa en su diversidad a nivel celular (inmunofenotípico), transcripcional y genético (inmunogenético). Se han logrado avances significativos en la comprensión de las características ...

HLA-specific memory B cells in kidney transplantation: A novel approach to humoral alloreactivity assessment 

Sanz Ureña, Sara (Date of defense: 2025-05-27)

L'estratificació del risc immunològic dels pacients és un punt crític per accedir al trasplantament renal. Avui dia, en la pràctica clínica només es tenen en compte els anticossos HLA detectats en sèrum, mentre que l’estudi ...

Mouse Models to Investigate the Molecular Mechanisms and Potential Biomarkers of the Central and Peripheral Co-morbidities of Chronic Pain 

Rodríguez López, Andrea (Date of defense: 2025-05-08)

La fibromiàlgia i l’osteoartritis són dues patologies doloroses que afecten significativament el benestar dels qui les pateixen i presenten reptes en el seu tractament. La seva prevalença i complexitat simptomatològica ...

Deciphering the mechanisms of skeletal muscle aging 

Ramírez Pardo, Ignacio (Date of defense: 2025-07-18)

La pèrdua de massa muscular i força durant l’envelliment compromet l’activitat locomotora i la qualitat de vida de la gent gran, així com també incrementa el seu risc de mortalitat i de patir comorbiditats. Per a comprendre ...

Oligonucleotide-Drug Conjugates and Alternative Methods to Selectively Reactivate the Inactive X-Chromosome in Female Somatic Cells 

Grimm, Niklas Benedikt (Date of defense: 2025-06-03)

En aquesta tesi, proporciono evidència que un inhibidor de DNMT1 pot ser enriquit en un únic cromosoma mitjançant la conjugació amb un oligonucleòtid antisentit. Aquest nou tipus de bioconjugat, anomenat conjugat ...

Genome-wide approach to the evolution and dynamics of Neotropical primate populations 

Hermosilla Albala, Núria (Date of defense: 2025-06-02)

Els primats neotropicals (platirrins) estan clarament infrarepresentats en estudis genòmics, tot i ser el grup de primats més divers del planeta i enfrontar-se a greus amenaces antropogèniques. Tradicionalment, la seva ...

Using Air Pollution Prediction for Multi-Pollutant Health Impact Assessment in European Regions 

Chen, Zhaoyue (Date of defense: 2025-05-28)

Aquesta tesi doctoral investiga l'exposició de la població als contaminants atmosfèrics, i els seus efectes sobre la salut humana a Europa, en un context de canvi climàtic i polítiques de mitigació de la contaminació ...

The measuring mind: cognitive mechanisms of rhythm and meter perception in humans and rats 

Mayayo Marsal, Ferran (Date of defense: 2025-05-21)

El ritme és un component fonamental de la música, la parla i el moviment. En música, la pulsació i la mètrica són elements clau del ritme. La pulsació es defineix com una regularitat rítmica subjacent, mentre que la mètrica ...

Spatial data science approaches to predict environmental and socioeconomic health determinants 

Milà Garcia, Carles (Date of defense: 2025-05-22)

Aquesta tesi, organitzada en tres articles, proposa avenços metodològics en els processos de predicció espacial utilitzats per a exposicions ambientals i socioeconòmiques. El primer estudi prediu la temperatura i quatre ...

Behavioral and molecular effects of environmental and genetic chronodisruption in mice 

Berbegal Sáez, Paula (Date of defense: 2025-06-12)

Els ritmes circadians regulen funcions fisiològiques essencials, permetent l’adaptació als canvis ambientals. La disrupció d’aquest sistema pot provocar desequilibris homeostàtics amb possibles conseqüències per a la salut. ...

Electrical source imaging and intracranial recordings in epilepsy: a prospective concordance study 

Ley Nácher, Miguel (Date of defense: 2025-06-03)

Introduction: Epilepsy is a prevalent neurological disorder affecting a significant portion of the population (prevalence of 1%). Approximately one-third of epilepsy patients exhibit drug resistance, posing challenges for ...

Development of prognostic models for resected distal cholangiocarcinoma 

Pérez Xaus, Marc (Date of defense: 2025-05-30)

Distal cholangiocarcinoma is a biliary malignancy associated with poor oncological outcomes with a 5-year survival rate after surgery from 16% to 39.5%. There’s an urgent need to develop a valid prognostic model that ...

Surveillance of non-fatal suicidal behaviour in Catalonia (Spain) through regional-based health registers 

Puértolas Gracia, Beatriz (Date of defense: 2025-05-19)

Antecedentes La conducta suicida es un problema complejo cuyo abordaje desafía a las sociedades y los sistemas gubernamentales. El presente estudio tiene como objetivos: estimar la incidencia de la conducta suicida en ...

Studying gene expression dynamics by integrating multiple Omics data 

Ntasis, Vasileios F. (Date of defense: 2025-05-12)

This thesis investigates the complex processes governing gene expression, from RNA transcription to protein synthesis, across diverse regulatory layers and biological contexts. By examining RNA localization between nuclear ...

Immunotherapeutic strategies for HIV cure: advancements in the characterisation and development of novel immune checkpoints therapeutics for combinatorial HIV1 immune interventions 

Marín López, Miguel Ángel (Date of defense: 2024-04-29)

Human Immunodeficiency Virus Type 1 (HIV-1) remains a global pandemic requiring the development of curative strategies due to the limitations of current antiretroviral treatments (ART). This thesis focuses on the need for ...

A Model of mammary microvasculature: evaluating hormone responsiveness and luminal-like tumor integration 

Moccia, Carmen (Date of defense: 2024-04-12)

This thesis aims to fill gaps in the research on breast microvasculature by creating a perfusable microvasculature system within a microfluidic platform. For the first time, we co-cultured primary breast endothelial cells ...

Unravelling new targets for pancreatic cancer: Galectin-1 and Parp-2 

Manero Rupérez, Noemí (Date of defense: 2023-03-30)

Pancreatic ductal adenocarcinoma (PDAC) is an unmet medical need characterized by a poor prognosis and high mortality. Until now, no effective therapies have been discovered to achieve disease control. Thus, there is an ...

Engineering TGF-B resistant NK cells for cancer immunotherapy 

Rea, Anna (Date of defense: 2023-03-02)

Natural killer (NK) cells are cytotoxic innate lymphocytes which can recognize tumor targets or virus-infected cells. Adoptive transfer of primary or genetically engineered NK cells for cancer immunotherapy is an attractive ...

Biotechnologies of the future: novel cyanobacteria-based solutions for sustainable industries 

Kheirabadi, Elaheh (Date of defense: 2024-02-22)

This thesis delves into the indispensable role of bacteria across our planet and their profound impact on various industries, encompassing health, agriculture, cosmetics, and materials science. It sheds light on the inherent ...

Mechanobiology of apoptotic cell clearance in the early embryo 

Batet Palau, Marta (Date of defense: 2025-04-09)

Spontaneous cellular errors can lead to cell death already in early embryo development. Apoptotic cell clearance is thus essential for tissue homeostasis and embryo survival. The outer epithelial layer of the embryo ...