Universitat Pompeu Fabra
Now showing items 539-558 of 1298
L’oxidació de la histona 3 en la lisina 4 (H3K4ox) per acció de la lysil oxidase-like 2 (LOXL2) genera una nova modificació de la H3 amb una funció desconeguda. En aquesta tesi, hem determinat tant en línies cel·lulars com ...
Esta tesis aborda la malnutrición y la sarcopenia en pacientes con enfermedades crónicas, centrándose en la enfermedad pulmonar obstructiva crónica (EPOC) y la enfermedad renal crónica. Utilizando los criterios de la Global ...
Morphogenesis creates a plethora of complex shapes in plants and animals. We devote this work to the study of Drosophila head involution (HI), a late embryogenetic process, which involves complete rearrangement of the head ...
The continuing growth of older age groups worldwide needs an increased understanding of the ageing phenomena. For this reason, the present thesis is aimed at two very important outcomes in the elderly, active ageing (AA) ...
The evaluation of olive oil antioxidants, hydroxytyrosol and tyrosol, in vivo biological activities is challenged due to scarce data on their metabolic disposition and activities of their glucuronides, main metabolites ...
Exposure to traffic-related air pollution (TRAP) has been associated with adverse health outcomes. Physical activity (PA) in polluted air may increase pollutant uptake and hence affect health. The main aim of this thesis ...
Urbanization processes are ongoing. Some aspects of urban life such as a sedentary lifestyle, the risk of traffic incidents, high levels of air pollution, noise and heat, and a lack of green spaces can have detrimental ...
The rapid increase in urbanization underscores the need for healthy urban environments. Presently, European cities experience high levels of air pollution, noise, lack of green spaces, and increased local temperatures, all ...
Objective: To examine health inequities in the working population of Latin America and the Caribbean (LAC) according to sex, age, level of study, occupation and formality or informality in employment. Methods: We collected ...
Harm reduction is a set of programs and interventions that aim to reduce health and social harms of drug use. The Barcelona model aims to maximize access to harm reduction services and to integrate them with treatment ...
Although heterochromatin is enriched with repressive traits, it is actively transcribed, giving rise to large amounts of non-coding RNAs. These transcripts are responsible for the formation and maintenance of heterochromatin, ...
Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. Preterm newborns require special care for surviving and may develop severe diseases related to prematurity, especially those born very early. ...
Thanks to advances in sequencing technologies, biomedical research has experienced a revolution over recent years, resulting in an explosion in the amount of genomic data being generated worldwide. The typical space ...
The rapid development of high-throughput sequencing technologies pushed forward the fields of medical genomics and precision medicine, creating many new applications for diagnostics and clinical studies that require high ...
The hindbrain boundary cell population (BCP) is specified at the interface between adjacent compartments during embryonic development of the posterior brain. Hindbrain BCP is a non-neurogenic population that acts as both ...
Esta tesis doctoral está basada en el estudio de los factores determinantes de la duración de la incapacidad temporal por contingencia común (ITcc). Se examina la variabilidad geográfica de la duración de la ITcc entre ...
Las enfermedades genéticas se clasifican típicamente en dos grandes grupos: las enfermedades mendelianas y las enfermedades complejas. Mientras que las enfermedades mendelianas se caracterizan por ser de baja frecuencia ...
This work describes the discovery and optimization of efficient, selective, cost-effective and proteolytic-resistant antimicrobial and antitumoral peptides. To this end, we first identified novel cathelicidin-related ...
Classically it was assumed that the compounds with therapeutic effect exert their action interacting with a single receptor. Nowadays it is widely recognized that the pharmacological effect of most drugs is more complex ...
Las hormonas tiroideas (HT) son esenciales para el desarrollo normal del cerebro. El desbalance tiroideo en la etapa fetal y postnatal puede producir retraso neuroconductual. La exposición a compuestos organoclorados (OCs) ...
