Mostrando ítems 41-50 de 158
Abate-Daga, Daniel (Fecha de defensa: 2009-04-17)
El sistema TK/GCV es, problamente, la estrategia suicida mejor caracterizada hasta el momento. No obstante, se desconocen muchos aspectos relacionados con su mecanismo de acción. Con el objetivo de ...
Marín López, Manuel Alejandro (Fecha de defensa: 2017-01-13)
Proteins are involved in almost all cell processes, with physical interaction between them being key to their function and dictated by its 3D structure. Hence, the study of protein-protein interactions ...
Radchenko, Tatiana L. (Fecha de defensa: 2018-09-28)
The work of this thesis aims to develop of a new workflow to predict potential Sites of Cleavage (SoCs) in new candidate peptide drugs. The main goal of this workflow is to understand the protease ...
Generoso, Serena Francesca (Fecha de defensa: 2019-03-21)
X-Chromosome Reactivation (XCR) occurs in the epiblast cells of the blastocyst and in germ cells, thereby coupling XCR with pluripotency. We performed a screen in iPS cells by knocking down the expression ...
Ferruz Capapey, Noelia (Fecha de defensa: 2016-03-04)
Understanding how receptor-ligand interactions occur is a first step towards designing new drugs. The complete reconstruction of the binding process in a drug-receptor system provides all the ...
Balsiger, Alexander (Fecha de defensa: 2014-12-19)
We recently identified a novel cyclin called Cyclin O which is able to bind and activate Cdk1 and Cdk2 in response to intrinsic apoptotic stimuli like DNA damage or ER stress. Cyclin O has been shown ...
Guidi, Mònica (Fecha de defensa: 2009-01-13)
Neurotrophins and their receptors are key molecules in the development of the<br/>nervous system. Neurotrophin-3 binds preferentially to its high-affinity receptor<br/>NTRK3, which exists in two major ...
Blasco Moreno, Bernat (Fecha de defensa: 2016-06-03)
The exonuclease Xrn1 degrades messenger RNAs (mRNAs) and controls transcription. By using a model system that replicates brome mosaic virus (BMV) in yeast, here we show that Xrn1 promotes translation ...
Álvarez Pedrerol, Mar (Fecha de defensa: 2010-07-19)
Las hormonas tiroideas (HT) son esenciales para el desarrollo normal del cerebro. El desbalance tiroideo en la etapa fetal y postnatal puede producir retraso neuroconductual. La exposición a compuestos ...
Rodríguez Torrecillas, Ivan (Fecha de defensa: 2015-12-14)
ABC (ATP-binding cassette) transporters are involved in translocate a wide spectrum of molecules across the lipid bilayer and some of them are associated with various diseases. They also have an ...