Ramos Fernández, Eva (Date of defense: 2013-01-16)
Nitric oxide (NO) is a molecule that has pleiotropic effects in brain and vascular system. Physiologically, NO induces the translation of the GluN2B subunit of N-methyl Daspartate receptor (NMDARc) ...
Valls Comamala, Victòria (Date of defense: 2018-09-07)
Aging is the main challenge that humanity will face on the near future. Brain aging is associated with cognitive deficiencies and is the main risk factor for Alzheimer’s Disease (AD). AD is the most ...
Picón Pagès, Pol (Date of defense: 2022-09-09)
Society increase in live expectancy will cause a rise in Alzheimer’s Disease (AD) diagnosis, thus, there is a need to further understand how it works. One of the main culprits of this disease amyloid-β ...
Vicario Orri, Elena (Date of defense: 2017-10-03)
The mechanisms by which amyloid beta (Aβ) causes synaptic dysfunction in Alzheimer’s disease (AD) remain elusive. Aβ is derived by sequential cleavage of the amyloid precursor protein (APP) and released ...
Guix Ràfols, Francesc Xavier (Date of defense: 2009-01-22)
Aquesta tesi demostra que el peroxinitrit produït com a conseqüència del pèptid beta-amiloide (A) contribueix l'augment de la relació A42/A40 que ocorre a la malaltia d'Alzheimer. ...
Godoy Zeballos, Juan Alejandro (Date of defense: 2018-06-29)
Las mitocondrias y su función metabólica cambian con el envejecimiento y pueden ser el factor más importante en el desarrollo de diferentes enfermedades neurodegenerativas relacionadas con la edad, ...
Coma Camprodón, Mireia (Date of defense: 2007-06-08)
En aquest treball de tesis doctoral s'estudia el paper de l'estrès oxidatiu tant a la etiologia com a la patofisiologia del dany vascular associat a la malaltia d'Alzheimer. Es demostra la capacitat de ...
Guivernau Almazán, Biuse (Date of defense: 2016-06-10)
Aggregation of the amyloid-β (Aβ) peptide to form oligomers and amyloid fibrils is a central event in the pathogenesis of Alzheimer’s disease (AD). This thesis aims to provide a better understanding of ...
Ill-Raga, Gerard (Date of defense: 2010-09-28)
Nitric oxide (NO) is a neurotransmitter involved in memory processes. Currently, the only recognized physiological signalling pathway controlled by NO is the activation of guanylyl cyclase. In this ...