Programa de Doctorat en Biomedicina: Envíos recientes
Mostrando ítems 1-20 de 1383
Structural basis of the early exocytosis : a spatio-temporal model of the vesicle tethering machinery
El proyecto tiene como objetivo general descifrar el mecanismo de la exocitosis utilizando biología estructural integrativa, lo cual ayudará a entender cómo las células controlan su crecimiento. Para ello, planteamos generar ...
New insights in cell cycle and meiosis regulation in fission yeast
This thesis is divided into three different sections. The first two sections involve the study of cell cycle and the third section is focused on meiosis. In the first chapter, we have developed a fluorescent-localized cell ...
Implicaciones clínicas de las pruebas de imagen en la evaluación de la sarcopenia asociada a las bronquiectasias
La bronquiectasia es una enfermedad pulmonar compleja cuyas manifestaciones sistémicas han sido poco estudiadas. La presente tesis explora en profundidad la presencia y características de la sarcopenia en pacientes con ...
Ablation of Glut1 drives oxidative phosphorylation and enhances antihumor activity in CD8+ T Cells
The thesis explores the potential of Glut1 ablation to enhance the antitumor activity of CD8+ T cells by inducing a metabolic shift from glycolysis to oxidative phosphorylation. Glut1-KO CD8+ T cells exhibited significantly ...
Adaptative mechanisms of sleep for cognition and memory
Durant el son, els estímuls sensorials externs es filtren mentre el cervell es prepara per consolidar nous records. Aquest equilibri sorgeix d’alternar recursos endògens entre la vigilància de l’entorn i la consolidació ...
Charting the alternative splicing vulnerabilities of cancer
Cancer co-opts alternative splicing to select isoforms that promote disease initiation, progression, and persistence. Drugs targeting either cancer driver splicing factors or specific splicing events can hamper the disease. ...
Attributing heat-related mortality to climate change
Climate change significantly exacerbates public health risks, particularly heat-related mortality. This PhD thesis examines the impact of human-induced climate change on heat-related deaths in Europe, focusing on regional ...
Evaluación del valor pronóstico de la ecografía pulmonar en el infarto agudo de miocardio con elevación del ST (LUS-AMI)
La insuficiencia cardíaca (IC) es un factor pronóstico crucial en pacientes con infarto agudo de miocardio con elevación del ST (IAMEST). La ecografía pulmonar es una técnica ampliamente estudiada en pacientes con insuficiencia ...
New insights into the clinical utility of LMO2
This thesis offers novel information on the clinical utility of LMO2, shown in three different studies. In the first one, we generated a round-robin testing validating the interobserver and interlaboratory reproducibility ...
A novel computational framework for identifying epileptogenic networks based on functional connectivity changes
Esta tesis se centra en mejorar la precisión de los objetivos quirúrgicos en pacientes con epilepsia resistente a los fármacos. Las redes cerebrales epileptogénicas exhiben cambios significativos en la conectividad durante ...
El impacto de la vivienda cooperativa en la salud de las personas: compartir para vivir
El objetivo principal de esta tesis ha sido profundizar y ampliar en el conocimiento sobre la vivienda cooperativa y su impacto en la salud de las personas. Para alcanzar este objetivo, se han diseñado y llevado a cabo ...
Evaluation of topoisomers of snake venom-derived peptides as potential antimicrobial and antitumor agents
This thesis reports an investigation of the effect of topoisomeric modification on the activity of two peptides: crotalicidin (Ctn), a cathelicidin from the venom of a South American rattlesnake, and Ctn[15-34], a Ctn ...
Evolutionary dynamics of cancer drug resistance and prediction of tumor modes of growth
Cancer remains a significant challenge in healthcare and is a leading concern worldwide. Despite advances in cancer therapy and the identification of numerous actionable events, relapse and drug resistance continue to ...
Novel experimental strategies to characterize the genomic architecture of monogenic autoinflammatory diseases: from characterization of aberrant mRNA transcripts to elucidation of the role of post-zygotic variants in desease pathogenesis
Developments in sequencing technologies over the last decade have revolutionized the ability to identify the genetic mechanisms underlying rare autoinflammatory diseases (AIDs), enabling improved characterization and ...
The molecular mechanism of spindle pole focusing: NuMA as a dynein adaptor and microtubule minus end regulator
This project investigates the molecular mechanisms underlying chromosome segregation during eukaryotic cell division. Specifically, it explores the role of the motor protein cytoplasmic dynein 1 in maintaining metaphase ...
Unravelling the molecular pathways of auditory and vestibular function: the roles of sall1a and the fgf13 genes in the zebrafish inner ear development
L’oïda interna és un òrgan sensorial complex essencial per a les funcions auditiva i vestibular, que depèn de les cèl·lules ciliades per a la mecanotransducció i de les neurones sensorials per a transmetre senyals al sistema ...
New strategies for targeting transactivation domains: insights from the androgen receptor
Transcription factors are, in theory, ideal targets for developing new therapies, as they drive the expression of genes, oftentimes those that lead to pathologies. However, these proteins typically contain large intrinsically ...
Skin microbiome engineering: new generation of therapeutics: engineering Cutibacterium acnes to treat skin conditions
We are living in a symbiotic relationship with our Microbiome. This relationship with our microbes can become opportunistic and lead to dysbiosis. While we were previously treating dysbiosis with antimicrobial drugs, we ...
Elucidating the dynamics of the 3D GPCRome
G Protein-Coupled Receptors (GPCRs) are a diverse protein family integral to a wide range of physiological processes. Although their three-dimensional structures have been extensively characterised through experimental ...
The KANSL complex, an epigenetic regulator with microtubule binding properties in mitosis
La segregació dels cromosomes durant la divisió cel·lular està mitjançada per una estructura feta de microtúbuls anomenada el fus mitòtic. L’estructura i la funció del fus mitòtic depenen d’un control precís de les dinàmiques ...
