Análisis de la respuesta neuromuscular y la proyección del ángulo de la rodilla en el plano frontal en sujetos físicamente activos: implicaciones para la lesión de ligamento cruzado anterior 

    Llurda Almuzara, Luis (Date of defense: 2022-07-12)

    La lesión de ligamento cruzado anterior es una de las lesiones más devastadoras en el ámbito deportivo. El valgo dinámico de rodilla durante el gesto deportivo puede ser uno de los mecanismos más comunes en la lesión del ...

    A bioengineering approach for corneal endothelial regeneration. 

    Bosch Canals, Begoña María (Date of defense: 2019-07-16)

    Nowadays, there are approximately 10 million people worldwide with visual impairment due to corneal diseases. Currently, the main therapeutic solution is the transplant of a donor's cornea. The great majority of transplants ...

    Caracterización cuantitativa de las ciclinas de la fase G1 del ciclo celular en Saccharomyces cerevisiae 

    Bállega Moreno, Elisabet (Date of defense: 2017-07-11)

    Saccharomyces cerevisiae és un microorganisme unicel·lular eucariota que per presentar el seu genoma totalment seqüenciat, gran facilitat de manipulació en el treball de laboratori, ja que molts dels seus gens es troben ...

    Caracterización de complejos CDK-Ciclina atípicos humanos 

    Quandt Herrera, Eva (Date of defense: 2017-11-16)

    La desregulación en los mecanismos de control del ciclo celular es un evento indiscutiblemente asociado a la aparición de diversas patologías, entre las que destacan los procesos tumorales. Como principales reguladores del ...

    Caracterización molecular de nuevos substratos de la CDK Pho85 

    Ricco Pacheco, Natalia (Date of defense: 2013-07-23)

    La ciclina Cln3 es un activador crítico de START, cuya sobreexpresión provoca células de menor tamaño que progresan rápidamente por el ciclo celular, mientras que su deleción induce un mayor tamaño de las células y retrasa ...

    CDK-mediated phosphorylation of Yku80 and its role in DNA repair 

    Carballar Ruiz, María de los Reyes (Date of defense: 2021-02-25)

    DNA double-strand breaks (DSBs) are considered the most deleterious lesions of DNA and they are repaired by means of two main mechanisms: homologous recombination (HR) and non-homologous endjoining (NHEJ). These mechanisms ...

    Control de la estabilidad de ciclinas de G1 por nutrientes 

    Hernández Ortega, Sara (Date of defense: 2014-07-18)

    El control del ciclo celular está altamente regulado mediante diferentes CDKs asociadas a ciclinas. En Saccharomyces cerevisiae, la CDK esencial Cdc28 es la que regula mayoritariamente este proceso. En la fase G1 del ciclo ...

    CPT1C and endocannabinoids as hypothalamic players in early stages of obesity development 

    Miralpeix Monclús, Cristina (Date of defense: 2019-12-04)

    Obesity prevalence in worldwide population is increasing every day due to an imbalance between the energy intake and the energy expenditure. Rich-caloric food is highly palatable and easily accessible, whereas sedentary ...

    CPT1c in specific hypothalamic nuclei and its role in lipid sensing and metabolic adaptation 

    Fosch Masllovet, Anna (Date of defense: 2022-07-28)

    Obesity has become a pandemic disease in the last 40 years. The WHO estimates that the population with overweight has nearly tripled since 1975, and the tendency is still growing. These data have an impact on health and ...

    CPT1C-dependent regulation of GluA1 trafficking under metabolic stress 

    Casas Prat, María (Date of defense: 2019-11-18)

    Carnitine palmitoyltransferase 1C (CPT1C) is the brain-specific isoform of the CPT1 family which is located at the endoplasmic reticulum (ER) of neurons and exhibits low catalytic activity, but still maintains the capacity ...

    El polifosfat és un element clau durant la replicació del DNA. 

    Bru Rullo, Samuel (Date of defense: 2015-07-20)

    Throughout its lifespan, eukaryotic cells steadily consume free cytoplasmic orthophosphate to produce phospholipids and mRNA. However, during DNA synthesis, in a matter of minutes, cells require large amount of phosphate ...

    Estudi de la ciclina atípica CCNI com a potencial activador de CDK6 en línies de càncer de mama 

    Masip Sales, Núria (Date of defense: 2022-01-27)

    Fa quasi 40 anys del descobriment de les ciclines, les proteïnes oscil·lants tradicionalment dividies en dos grups, “cicle cel·lular” i “ciclines transcripcionals”, que duen a terme els seus rols juntament amb la seva ...

    Evaluation of the impact of Spanish smoking legislation on tobacco consumption and passive exposure 

    Lidón Moyano, Cristina (Date of defense: 2017-10-06)

    In Spain, two smoke-free laws have been passed after the approval of the FCTC. In 2005, it came into effect a smoke-free legislation (Law 28/2005). This law was a great advance for public health in Spain; however, it was ...

    Expresión de factores de transcripción TCF7L2 durante la diferenciación in vitro de células de neuroblastoma inducida por el ácido retinoico. 

    Navarro Martínez, Lourdes (Date of defense: 2017-09-29)

    Las proteínas TCF7L2 (transcription factor 7-like 2) son un conjunto de factores de transcripción que participan en la vía Wnt y son responsables, entre otras funciones, del mantenimiento de las células madre y la formación ...

    Extracellular UTP signalling in Schwann cell migration: A novel role of the P2Y2 receptor 

    Lamarca Dams, Aloa (Date of defense: 2013-09-13)

    Peripheral neuropaties are one of the major complications of the Peripheral Nervous System. Depsite the big importance of those pathologies, less drugs are effective for their treatment, and most of the prescribed drugs ...

    Factores relacionados con el perdón: características de la ofensa, del ofensor y del ofendido. 

    Díez Deustua, Patricia (Date of defense: 2015-12-02)

    En el presente trabajo revisamos las diferentes variables que han sido asociadas al perdón. Son muchos los factores que influyen en que dicho proceso se lleve a cabo o no. Estudios previos han analizado la importancia ...

    G1-Cdk modulation by time and stress 

    Pérez Paredes, Alexis E. (Date of defense: 2022-07-22)

    The cell cycle is regulated at different layers of control in either homeostatic or non-homeostatic conditions. Hence, in this work we analyse how time and stress modulate the cell cycle through the activity of the G1 ...

    Hypothalamic Ceramide Levels regulated by CPT1C mediate the Orexigenic effect of Ghrelin 

    Ramírez Flores, Sara (Date of defense: 2014-07-18)

    Recent data suggest that ghrelin exerts its orexigenic action through regulation of hypothalamic AMP-activated protein kinase pathway, leading to a decline in malonyl-CoA levels and desinhibition of carnitine palmitoyltransferase ...

    Increasing Forgiveness: design of two brief techniques based on the Social Learning Theory. 

    Gámiz Sanfeliu, María (Date of defense: 2017-07-11)

    Forgiveness is a human strength mainly helpful for the wellbeing of social relationships. Research has showed the potential benefits of forgiving for physical and mental health as well as for restoring relationships. As a ...

    Iron Regulatory Protein/Iron Responsive Element (IRP/IRE) system: associated diseases and new target mRNAs (PPP1R1B) 

    Celma Nos, Ferran (Date of defense: 2022-05-17)

    Iron is a biometal involved in many physiological processes essential for life. Regulation of both systemic and cellular iron homeostasis is crucial for health. The IRP/IRE post-transcriptional regulatory system is in ...